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1. (WO2019046307) SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
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Pub. No.: WO/2019/046307 International Application No.: PCT/US2018/048353
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
B01L 3/00 (2006.01) ,G01N 33/00 (2006.01) ,G01N 33/06 (2006.01) ,G01N 30/26 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
02
Food
04
Dairy products
06
Determining fat content, e.g. by butyrometer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
26
Conditioning of the fluid carrier; Flow patterns
Applicants:
CELSEE DIAGNOSTICS, INC. [US/US]; 46701 Commerce Center Drive Plymouth, MI 48170, US
Inventors:
HANDIQUE, Kalyan; US
SHARMA, Vishal; US
GOGOI, Priyadarshini; US
CHOW, William; US
PAYNE, Austin; US
BONIFACE, Brian; US
GLEASON, Kyle; US
CONNOLLY, John; US
TUCK, Sam; US
Agent:
SCHOX, Jeffrey; US
Priority Data:
62/551,57529.08.2017US
62/671,75015.05.2018US
Title (EN) SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
(FR) SYSTÈME ET PROCÉDÉ POUR ISOLER ET ANALYSER DES CELLULES
Abstract:
(EN) A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: distributing a population of cells and a population of non-cell particles across the array of wells through the fluid reservoir to increase capture efficiency of individual cell-particle pairs within the array of wells, and processing the captured cell-particle pairs at the set of wells.
(FR) L'invention concerne un système et un procédé permettant d'isoler et d'analyser des cellules individuelles, le système comprenant : un réseau de puits définis au niveau d'un substrat, chaque puits comprenant une surface ouverte et une cavité de puits configurée pour capturer des cellules dans un format de cellule unique et un format de groupe unique, et un module de distribution de fluide comprenant un réservoir de fluide supérieur au réseau de puits à travers lequel un écoulement de fluide est commandé le long d'un chemin de fluide dans une direction parallèle à la face large du substrat; et le procédé comprenant : la distribution d'une population de cellules et d'une population de particules non cellulaires à travers le réseau de puits à travers le réservoir de fluide pour augmenter l'efficacité de capture de paires de particules de cellules individuelles à l'intérieur du réseau de puits, et le traitement des paires de particules de cellules capturées au niveau de l'ensemble de puits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)