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1. (WO2019046293) SUSTAINED-RELEASE ANESTHETIC COMPOSITIONS AND METHODS OF PREPARATION THEREOF
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Pub. No.: WO/2019/046293 International Application No.: PCT/US2018/048329
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 9/00 (2006.01) ,A61K 9/107 (2006.01) ,A61K 9/127 (2006.01) ,A61K 31/167 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
Applicants:
TLC BIOPHARMACEUTICALS, INC. [US/US]; 432 North Canal Street, #20 South San Francisco, CA 94080, US
TAIWAN LIPOSOME CO., LTD.; 11F-1, No. 3 Yuanqu Street, Nangang District Taipei City 11503, TW
Inventors:
HONG, Keelung; US
KAO, Hao-Wen; TW
LIN, Yi-Yu; TW
GUO, Luke, S.s.; US
Agent:
VAN HORN, Charles, E.; US
SWEET, Mark, D.; US
LEIMAN, Sara, A.; US
STRAUSS, William, L.; US
Priority Data:
62/550,98328.08.2017US
62/621,73025.01.2018US
Title (EN) SUSTAINED-RELEASE ANESTHETIC COMPOSITIONS AND METHODS OF PREPARATION THEREOF
(FR) COMPOSITIONS ANESTHÉSIQUES À LIBÉRATION PROLONGÉE ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract:
(EN) Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with en trapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
(FR) La présente invention concerne une composition anesthésique pour administrer localement un anesthésique de type amide à un sujet en ayant besoin. La composition anesthésique possède des vésicules multilamellaires avec un anesthésique de type amide piégé préparé par hydratation d'une structure lipidique hautement piégée comprenant un anesthésique de type amide et un mélange lipidique avec une solution tampon aqueuse à un pH supérieur à 5,5. L'invention concerne également un procédé de préparation d'une composition anesthésique à l'aide d'un procédé plus simple et plus réalisable pour une fabrication à grande échelle et pour fournir un rapport molaire élevé d'anesthésique de type amide à un contenu phospholipidique par comparaison avec l'état de la technique. Ladite composition anesthésique a une durée d'efficacité prolongée adaptée à l'administration de médicaments.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)