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1. (WO2019046278) PAYLOAD AND LINKER DESIGNS FOR PLATINUM-ACRIDINE ANTICANCER AGENTS AND METHODS THEREOF
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Pub. No.: WO/2019/046278 International Application No.: PCT/US2018/048309
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A01N 43/62 (2006.01) ,A61K 31/282 (2006.01) ,C07D 219/00 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
62
three- or four-membered rings or rings with more than six members
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
219
Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
Applicants:
WAKE FOREST UNIVERSITY [US/US]; 391 Technology Way Suite 199 Winston-Salem, NC 27101, US
Inventors:
BIERBACH, Ulrich; US
YAO, Xiyuan; US
WANG, Hanwen; US
Agent:
NORTON, Gerard, P.; US
ZHU, Jin; US
BARRISON, Flynn; US
Priority Data:
62/550,81728.08.2017US
Title (EN) PAYLOAD AND LINKER DESIGNS FOR PLATINUM-ACRIDINE ANTICANCER AGENTS AND METHODS THEREOF
(FR) CONCEPTIONS DE CHARGES UTILES ET DE SEGMENTS DE LIAISON, DESTINÉES À DES AGENTS ANTICANCÉREUX ET PROCÉDÉS ASSOCIÉS
Abstract:
(EN) The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and / or enhance the activity of the platinum compound.
(FR) La présente invention concerne des charges utiles contenant des agents hybrides de platine-(benz)acridine fonctionnalisés en tant qu'armes de guerre cytotoxiques, ainsi qu'un procédé de synthèse de ces charges utiles. La charge utile peut être conjuguée de manière régiosélective à une fraction active biologiquement afin de faciliter l'apport et/ou améliorer l'activité du composé de platine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)