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1. (WO2019046271) HEPATITIS B ANTIVIRAL AGENTS
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Pub. No.: WO/2019/046271 International Application No.: PCT/US2018/048300
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A01N 33/06 (2006.01) ,A01N 41/06 (2006.01) ,A61K 31/167 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
33
Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
02
Amines; Quaternary ammonium compounds
06
Nitrogen directly attached to an aromatic ring system
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
41
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
02
containing a sulfur-to-oxygen double bond
04
Sulfonic acids; Derivatives thereof
06
Sulfonic acid amides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
Applicants:
ENANTA PHARMACEUTICALS, INC. [US/US]; 500 Arsenal Street Watertown, MA 02472, US
Inventors:
QIU, Yao-ling; US
CAO, Hui; US
GAO, Xuri; US
KASS, Jordan; US
LI, Wei; US
PENG, Xiaowen; US
SUH, Byung-chul; US
OR, Yat, Sun; US
Agent:
HARLAN, Edgar, W.; US
Priority Data:
62/550,99228.08.2017US
Title (EN) HEPATITIS B ANTIVIRAL AGENTS
(FR) AGENTS ANTIVIRAUX CONTRE L'HÉPATITE B
Abstract:
(EN) The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
(FR) La présente invention concerne des composés de formule (I), ou leurs sels, esters ou promédicaments pharmaceutiquement acceptables qui inhibent la ou les protéines encodées par le virus de l'hépatite B (VHB) ou qui interfèrent avec la fonction du cycle de vie du virus de l'hépatite B et sont également utiles en tant qu'agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés susmentionnés, destinées à être administrées à un sujet atteint d'une infection par le VHB. L'invention concerne encore des méthodes de traitement d'une infection par le VHB chez un patient, lesquelles méthodes de traitement consistent à administrer une composition pharmaceutique comprenant les composés de la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)