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1. (WO2019046233) A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS
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Pub. No.: WO/2019/046233 International Application No.: PCT/US2018/048240
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
C12Q 1/6883 (2018.01)
[IPC code unknown for C12Q 1/6883]
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
CARMAN, Julie; US
HU, Yanhua; US
Agent:
PARLET, Nickki L.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
CLAUSS, Isabelle M.; US
COULTER, Kathryn; US
DELAUNEY, Ashton J.; US
EPPERSON, James; US
FARQUHARSON-TORRES, Serena; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
HAI, Bing; US
JACOBSEN, Barry H.; US
KORSEN, Elliott; US
LAUB, Friedrich; US
LIU, Hong; US
MINGO, Pamela A.; US
SUN, Jing G.; US
VANATTEN, Mary K.; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
Priority Data:
62/551,83930.08.2017US
Title (EN) A METHOD TO MONITOR PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO ADMINISTRATION OF GLUCOCORTICOIDS
(FR) PROCÉDÉ DE SURVEILLANCE DE RÉPONSES PHARMACODYNAMIQUES MÉDIÉES PAR L'ADMINISTRATION IN VIVO DE GLUCOCORTICOÏDES
Abstract:
(EN) The present invention relates generally to a method of monitoring pharmacodynamic responses mediated by in vivo administration of glucocorticoids. More specifically, the present invention relates to a method of using a change in gene signature as a pharmacodynamic marker of glucocorticoid exposure.
(FR) La présente invention concerne de manière générale un procédé de surveillance de réponses pharmacodynamiques médiées par l'administration in vivo de glucocorticoïdes. La présente invention concerne plus particulièrement un procédé d'utilisation d'un changement de signature génique en tant que marqueur pharmacodynamique d'exposition aux glucocorticoïdes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)