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1. (WO2019046162) METHODS OF TREATING EPILEPSY, SEIZURE DISORDERS AND SUDDEN UNEXPECTED DEATH IN EPILEPSY
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Pub. No.: WO/2019/046162 International Application No.: PCT/US2018/048088
Publication Date: 07.03.2019 International Filing Date: 27.08.2018
IPC:
A61K 38/28 (2006.01) ,A61K 9/00 (2006.01) ,A61M 15/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
15
Inhalators
08
Inhaling devices inserted into the nose
Applicants:
HEALTHPARTNERS INSTITUTE [US/US]; 8170 33rd Avenue South Bloomington, Minnesota 55425, US
Inventors:
FREY II, William H.; US
BRESIN HANSON, Leah R.; US
Agent:
STONE, Jeffrey R.; US
Priority Data:
16/111,50024.08.2018US
62/550,85728.08.2017US
Title (EN) METHODS OF TREATING EPILEPSY, SEIZURE DISORDERS AND SUDDEN UNEXPECTED DEATH IN EPILEPSY
(FR) MÉTHODES DE TRAITEMENT DE L'ÉPILEPSIE, DE TROUBLES ÉPILEPTIQUES ET DE LA MORT SOUDAINE INATTENDUE EN CAS D'ÉPILEPSIE
Abstract:
(EN) The present system is directed in several embodiments to a method of administration of a therapeutic composition for treatment of seizures resulting from epilepsy and other seizure disorders. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's CNS, with no to minimal systemic exposure. Preferably, this method comprises administration of an effective amount of insulin to the upper third of a patient's nasal cavity, thereby bypassing the patient's blood-brain barrier and delivering the therapeutic composition directly to the patient's central nervous system.
(FR) La présente invention concerne, dans plusieurs modes de réalisation, une méthode d'administration d'une composition thérapeutique pour le traitement de crises résultant de l'épilepsie et d'autres troubles épileptiques. Ladite méthode consiste à administrer une ou plusieurs compositions thérapeutiques comprenant une dose efficace d'insuline directement dans le système nerveux central du patient, sans exposition systémique ou avec une exposition systémique minimale. De préférence, la méthode consiste à administrer une quantité efficace d'insuline dans le tiers supérieur de la cavité nasale d'un patient, ce qui permet de contourner la barrière hémato-encéphalique du patient et d'administrer la composition thérapeutique directement dans le système nerveux central du patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)