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1. (WO2019046126) AMINOGLYCOSIDES AND USES THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/046126 International Application No.: PCT/US2018/047969
Publication Date: 07.03.2019 International Filing Date: 24.08.2018
IPC:
A61K 31/7028 (2006.01) ,A61K 31/7034 (2006.01) ,A61K 31/7036 (2006.01) ,C07H 15/226 (2006.01) ,C07H 15/228 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
7036
having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20
Carbocyclic rings
22
Cyclohexane rings, substituted by nitrogen atoms
222
Cyclohexane rings, substituted by at least two nitrogen atoms
226
with at least two saccharide radicals directly attached to the cyclohexane rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20
Carbocyclic rings
22
Cyclohexane rings, substituted by nitrogen atoms
222
Cyclohexane rings, substituted by at least two nitrogen atoms
226
with at least two saccharide radicals directly attached to the cyclohexane rings
228
attached to adjacent ring-carbon atoms of the cyclohexane rings
Applicants:
ACHAOGEN, INC. [US/US]; 1 Tower Place, Suite 300 South San Francisco, California 94080, US
Inventors:
ANDREWS, Logan; US
CALABRESE, Andrew; US
KANE, Timothy Robert; US
CIRZ, Ryan; US
COHEN, Frederick; US
LOPEZ, Michael; US
KNOX, John; US
EVDOKIMOV, Nikolai; US
Agent:
TULLY, Sarah E.; US
TONG, Connie C.; US
BOLIN, Kimberly A.; US
FARMER, Dean; US
Priority Data:
62/551,10728.08.2017US
62/563,02525.09.2017US
62/652,16103.04.2018US
Title (EN) AMINOGLYCOSIDES AND USES THEREOF
(FR) AMINOGLYCOSIDES ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are aminoglycoside compounds, such as compounds of formula (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), or (VIIb) or pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers of any of the foregoing, useful as therapeutic or prophylactic agents. Also provided herein are methods for their preparation. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection.
(FR) La présente invention concerne des composés d'aminoglycosides, tels que des composés de formule (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), ou (VIIb) ou des sels, solvates, stéréoisomères, ou tautomères pharmaceutiquement acceptables de l'un quelconque des composés précédents, utiles à titre d'agents thérapeutiques ou prophylactiques. L'invention concerne également des procédés pour les préparer. Les composés selon l'invention peuvent être utiles dans le traitement d'une infection bactérienne chez un sujet, par exemple une infection bactérienne à Gram négatif.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)