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1. (WO2019045824) INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/045824 International Application No.: PCT/US2018/037305
Publication Date: 07.03.2019 International Filing Date: 13.06.2018
IPC:
A61K 31/506 (2006.01) ,C07D 237/26 (2006.01) ,C07D 403/14 (2006.01) ,C07D 487/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
08
Bridged systems
Applicants:
KADMON CORPORATION, LLC [US/US]; 450 East 29th Street New York, NY 10016, US
Inventors:
SKUCAS, Eduardas; US
LIU, Kevin, G.; US
KIM, Ji-In; US
POYUROVSKY, Masha, V.; US
MO, Rigen; US
Agent:
GLYNN, Christopher, W.; US
BARISSON, Flynn; US
FOIT, Linda; US
GLYNN, Michael, W.; US
SOMERVILLE, Deborah, A.; US
Priority Data:
62/553,61901.09.2017US
Title (EN) INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE
(FR) INHIBITEURS DE PROTÉINE KINASE À SUPERENROULEMENT D'HÉLICES ALPHA (« COILED-COIL ») ASSOCIÉE À RHO
Abstract:
(EN) The invention relates to inhibitors of ROCK1 and/or ROCK2. Also provided are methods of inhibiting ROCK1 and/or ROCK2 that are useful for the treatment of disease.
(FR) L'invention concerne des inhibiteurs de ROCK1 et/ou ROCK2. L'invention concerne également des procédés d'inhibition de ROCK1 et/ou de ROCK2 utiles pour le traitement d'une maladie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)