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1. (WO2019045775) IPSC-DERIVED SECRETOME COMPOSITIONS, AND RELATED SYSTEMS AND METHODS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/045775 International Application No.: PCT/US2018/022325
Publication Date: 07.03.2019 International Filing Date: 14.03.2018
IPC:
A61K 9/00 (2006.01) ,A61K 9/10 (2006.01) ,A61K 35/12 (2015.01) ,A61K 35/30 (2015.01) ,A61K 38/17 (2006.01) ,A61K 39/395 (2006.01) ,A61K 47/36 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
30
Nerves; Brain
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
Applicants:
ORIG3N, INC. [US/US]; 27 Drydock Ave., 6th Floor Boston, Massachusetts 02210, US
Inventors:
SMITH, Robin Y.; US
GLICKSMAN, Marcie A.; US
Agent:
HAULBROOK, William R.; US
ADATO, Ronen; US
AUGST, Alexander D.; US
BYCHOWSKI, Meaghan E.; US
BUTEAU, Kristen C.; US
CAHILL, John J.; US
JARRELL, Brenda Herschbach; US
KLEIN, Daniel A.; US
LI, Xiaodong; US
LUCA, Cassandra G.; US
LYON, Charles E.; US
MEDINA, Rolando; US
MONROE, Margo R.; US
NGUYEN, Suzanne P.; US
PACE, Nicholas J.; US
PYSHER, Paul A.; US
REARICK, John P.; US
REESE, Brian E.; US
ROHLFS, Elizabeth M.; US
SAHR, Robert N.; US
SCHONEWALD, Stephanie L.; US
SHAIKH, Nishat A.; US
SHINALL, Michael A.; US
SHORE, David E.; US
SMITH, Maria C.; US
SUH, Su Kyung; US
VETTER, Michael L.; US
VRABLIK, Tracy L.; US
Priority Data:
62/553,54501.09.2017US
62/592,26329.11.2017US
62/595,44706.12.2017US
Title (EN) IPSC-DERIVED SECRETOME COMPOSITIONS, AND RELATED SYSTEMS AND METHODS
(FR) COMPOSITIONS DE SÉCRÉTOMES DÉRIVÉS DE CELLULES SOUCHES PLURIPOTENTES INDUITES, ET SYSTÈMES ET PROCÉDÉS ASSOCIÉS
Abstract:
(EN) Presented herein are methods of producing "personalized" secretome compositions suitable for secretome based therapy to be administered to a specific individual and/or specific group of individuals. The iPSCs and/or iPSC-derived cells, and any iPSC-derived compositions derived therefrom, are identified as compatible with a specific individual or specific group of individuals using an identification of a cell type indicative of compatibility such as an HLA match and/or ABO blood match and/or RHD blood group match. The identified compatible cells are then retrieved from a managed HLA-indexed (and/or otherwise indexed) repository or are derived from a biological sample of a suitable donor. The retrieved compatible cells are then used to derive the "personalized" iPSC-derived secretome compositions, that comprise the complete secretome or a subset of the secretome suitable for treatment of a specific individual and/or specific group of individuals.
(FR) L'invention concerne des procédés de production de compositions de sécrétomes « personnalisées » appropriées pour une thérapie à base de sécrétomes à administrer à un individu spécifique et/ou à un groupe spécifique d'individus. Les cellules souches pluripotentes induites (iPSC) et/ou les cellules dérivées d'iPSC, et des compositions dérivées d'iPSC quelconques dérivées de celles-ci, sont identifiées comme étant compatibles avec un individu spécifique ou un groupe spécifique d'individus à l'aide d'une identification d'un type de cellule indiquant une compatibilité telle qu'une correspondance au système HLA et/ou une correspondance au système ABO et/ou une correspondance au système Rhésus). Les cellules compatibles identifiées sont ensuite récupérées d'un référentiel géré à indexation HLA (et/ou indexé autrement) ou sont dérivées d'un échantillon biologique d'un donneur approprié. Les cellules compatibles récupérées sont ensuite utilisées pour dériver les compositions de sécrétomes dérivés d'iPSC « personnalisées », qui comprennent le sécrétome complet ou un sous-ensemble du sécrétome approprié pour le traitement d'un individu spécifique et/ou d'un groupe spécifique d'individus.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)