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1. (WO2019045655) DERIVATIVES AND COMPOSITION OF QUINOLINE AND NAPHTHYRIDINE
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Pub. No.: WO/2019/045655 International Application No.: PCT/TH2017/000066
Publication Date: 07.03.2019 International Filing Date: 29.08.2017
IPC:
C07D 215/22 (2006.01) ,C07D 215/46 (2006.01) ,C07D 215/26 (2006.01) ,A61K 31/4706 (2006.01) ,A61K 31/4709 (2006.01) ,A61P 31/18 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
42
attached in position 4
46
with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
24
attached in position 8
26
Alcohols; Ethers thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4706
4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CHULABHORN FOUNDATION [TH/TH]; 54 Kamphaeng Phet 6 Road, Talat Bang Khen, Lak Si, Bangkok, 10210, TH
KASETSART UNIVERSITY [TH/TH]; 50 Ngam Wong Wan Rd, Ladyao, Chatuchak, Bangkok, 10900, TH
SRINAKHARINWIROT UNIVERSITY [TH/TH]; 114 Sukhumvit 23, Wattana District, Bangkok, 10110, TH
Inventors:
TECHASAKUL, Supanna; TH
MAKARASEN, Arthit; TH
REUK-NGAM, Nanthawan; TH
KHLAYCHAN, Panita; TH
KUNO, Mayuso; TH
HANNONGBUA, Supa; TH
Agent:
MONGKOLSIT, Chakrapat; TH
Priority Data:
Title (EN) DERIVATIVES AND COMPOSITION OF QUINOLINE AND NAPHTHYRIDINE
(FR) DÉRIVÉS ET COMPOSITION DE QUINOLÉINE ET DE NAPHTYRIDINE
Abstract:
(EN) Provided is compound of formula (I) where: X and Y may be identical or different and represent O, NH, or S; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, and R 10 may be identical or different and represent H, halogen, CN, NO 2, (C 1-4)alkyl, (C 1-4)haloalkyl, (C 2-4)alkenyl, OH, O(C 1-4)alkyl, O(C 1-4)haloalkyl, N(R A)R B, C(O)N(R A)R B, C(O)R A, CO 2R A, CHO, C 2-4alkenyl substituted with CN, C 2-4alkenyl substituted with COOH, C 2-4alkenyl substituted with CHO, or C 2-4alkenyl substituted with OH; R A and R B may be identical or different and represent H, (C 1-4)alkyl, (C 1-4)haloalkyl, or (C 2-4)alkenyl; A 1, A 2, A 3, and A 4 may be identical or different and represent CH or N with the proviso that A 1 and A 2 cannot be N and that R 5 and R 10 are absent when A 3 and A 4 are N; or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.
(FR) L'invention concerne un composé de formule (I) dans laquelle : X et Y peuvent être identiques ou différents et représentent O, NH ou S ; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, et R 10 peuvent être identiques ou différents et représentent H, halogène, CN, NO 2, alkyle en (C 1-4), haloalkyle en (C 1-4), alcényle en (C 2-4), OH, alkyle en O(C 1-4), haloalkyle en O(C 1-4), N(R A)R B, C(O)N(R A)R B, C(O)R A, CO 2R A, CHO, alcényle en C 2-4 substitué par CN, alcényle en C 2-4 substitué par COOH, alcényle en C 2-4 substitué par CHO, ou alcényle en C 2-4 substitué par OH ; R A et R B peuvent être identiques ou différents et représentent H, alkyle en (C 1-4), haloalkyle en (C 1-4), ou alcényle en (C 2-4) ; A 1, A 2, A 3, et A 4 peuvent être identiques ou différents et représentent CH ou N à condition que A 1 et A 2 ne puissent pas être N et que R 5 et R 10 sont absents lorsque A 3 et A 4 sont N ; ou un sel pharmaceutiquement acceptable de celui-ci, un stéréoisomère de celui-ci, ou un mélange comprenant des stéréoisomères dudit composé.
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African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)