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1. (WO2019045522) AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF
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Pub. No.: WO/2019/045522 International Application No.: PCT/KR2018/010154
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07F 7/08 (2006.01) ,A61K 49/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
Applicants:
포항공과대학교 산학협력단 POSTECH ACADEMY-INDUSTRY FOUNDATION [KR/KR]; 경상북도 포항시 남구 청암로 77 (지곡동) (Jigok-dong) 77, Cheongam-ro, Nam-gu, Pohang-si, Gyeongsangbuk-do 37673, KR
Inventors:
안교한 AHN, Kyo Han; KR
류혜근 RYU, Hye Gun; KR
김경환 KIM, Kyeong Hwan; KR
전용웅 JUN, Yong Woong; KR
싱하수방카 SINGHA, Subhankar; KR
Agent:
이명진 LEE, Myoung-Jin; KR
Priority Data:
10-2017-011070831.08.2017KR
10-2018-010277630.08.2018KR
Title (EN) AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF
(FR) SUBSTANCE FLUORESCENTE À ABSORPTION MONOPHOTONIQUE OU BIPHOTONIQUE À BASE DE COMPOSÉ AMINO-SILA-PYRONINE ET SON UTILISATION
(KO) 아미노-실라-파이로닌 화합물 기반 일광자 또는 이광자 흡수 형광체 및 이의 용도
Abstract:
(EN) The present invention relates to a silicon-substituted amino-pyronin compound derivative, a cell- or tissue-imaging method using the same, a cancer diagnosis method using the same, and a method for preparation of the same. More specifically, serving as a two-photon absorption fluorescent substance which has longer absorption and emission wavelengths in red or near-infrared regions of 625 nm or greater, compared to conventional one-photon absorption fluorescent substances, the silicon-substituted amino-pyronin compound derivative can minimize the influence of self-fluorescence in a bioimaging study and is thus expected to be suitable for high-resolution imaging in deep tissues. A fluorescent probe developed on the basis of the fluorescent substance platform is expected to find an expanded range of applications in analyzing and imaging specific materials in vivo.
(FR) La présente invention concerne un dérivé de composé amino-pyronine substitué par du silicium, un procédé d'imagerie de cellule ou de tissu l'utilisant, un procédé de diagnostic du cancer l'utilisant, et un procédé de préparation de celui-ci. Plus particulièrement, le dérivé de composé amino-pyronine substitué par du silicium, sert comme substance fluorescente à absorption biphotonique ayant des longueurs d'onde d'absorption et d'émission plus longues dans des régions rouge ou proche infrarouge de 625 nm ou plus, par comparaison avec des substances fluorescentes d'absorption monophotonique classiques. Le dérivé de composé amino-pyronine substitué par du silicium, selon l'invention, peut réduire au minimum l'influence de l'auto-fluorescence dans une étude de bio-imagerie et est ainsi susceptible d'être approprié pour une imagerie haute résolution dans des tissus profonds. Une sonde fluorescente développée sur la base de la plate-forme de substance fluorescente est susceptible de trouver une large gamme d'applications dans l'analyse et l'imagerie de matériaux spécifiques in vivo.
(KO) 본 발명은 실리콘 치환 아미노-파이로닌 화합물의 유도체, 이를 이용한 세포 또는 조직의 영상화 방법, 이를 이용한 암진단 방법 및 이를 제조하는 방법 등에 관한 것으로서, 더욱 구체적으로는 상기 실리콘 치환 아미노-파이로닌 화합물의 유도체는 이광자 흡수 형광체로, 종래 일광자 흡수 형광체에 비해 625 nm 이상의 적색 또는 근적외선 영역에서의 더 긴 흡수 및 방출 파장을 가지고 있어, 생체 영상화 연구에 있어서 자가 형광에 의한 영향을 최소화할 수 있는 바 깊은 조직에서의 고해상도 영상화에 적합할 것으로 기대된다. 상기 형광체 플랫폼을 기반으로 개발된 형광 프로브는 생체 내 특정 물질 분석 및 영상화에 있어 그 활용범위를 확장시킬 수 있을 것으로 기대된다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)