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1. (WO2019045436) GADOBUTROL INTERMEDIATE AND GADOBUTROL PRODUCTION METHOD USING SAME
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Pub. No.: WO/2019/045436 International Application No.: PCT/KR2018/009956
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07D 257/02 (2006.01) ,A61K 49/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
Applicants:
주식회사 엔지켐생명과학 ENZYCHEM LIFESCIENCES CORPORATION [KR/KR]; 대전시 유성구 문지로 193, KAIST-ICC 제F741호 KAIST-ICC F741 193, Munji-ro, Yuseong-gu, Daejeon 34051, KR
Inventors:
이재용 LEE, Jae Yong; KR
이종수 LEE, Jong Soo; KR
강병규 KANG, Byung Kyu; KR
이상오 LEE, Sang Oh; KR
이병우 LEE, Byuong Woo; KR
윤대명 YUN, Dae Myoung; KR
방제훈 BANG, Jae Hun; KR
최경석 CHOI, Kyung Seok; KR
Agent:
특허법인 신우 SHINWOO PATENT & LAW FIRM; 서울시 강남구 테헤란로21길 8, 6층 6F, 8, Teheran-ro 21-gil, Gangnam-gu, Seoul 06132, KR
Priority Data:
10-2017-010967729.08.2017KR
Title (EN) GADOBUTROL INTERMEDIATE AND GADOBUTROL PRODUCTION METHOD USING SAME
(FR) INTERMÉDIAIRE DE GADOBUTROL ET PROCÉDÉ DE PRODUCTION DE GADOBUTROL L’UTILISANT
(KO) 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
Abstract:
(EN) Disclosed are: an intermediate capable of high-purity synthesis of gadobutrol which can be used as an MRI contrast agent; and a gadobutrol production method using same. The gadobutrol intermediate is represented by Chemical Formula 2 in the specification.
(FR) L'invention concerne : un intermédiaire de synthèse en haute pureté de gadobutrol qui être utilisé en tant qu'agent de contraste d'IRM ; et un procédé de production de gadobutrol utilisant ledit intermédiaire de gadobutrol. L'intermédiaire de gadobutrol est représenté par la formule chimique 2 dans la spécification.
(KO) MRI 조영제로 사용되는 가도부트롤을 고순도로 합성할 수 있는 중간체 및 이를 이용한 가도부트롤의 제조 방법이 개시된다. 상기 가도부트롤 중간체는 명세서의 화학식 2로 표시된다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)