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1. (WO2019045116) PROPHYLACTIC OR THERAPEUTIC AGENT FOR CONFORMATIONAL DISEASES, AND SCREENING METHOD FOR CONFORMATIONAL DISEASE DRUGS
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Pub. No.: WO/2019/045116 International Application No.: PCT/JP2018/032729
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
C07K 19/00 (2006.01) ,A61K 39/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/02 (2006.01) ,A61P 25/14 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/28 (2006.01) ,G01N 33/15 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
02
for peripheral neuropathies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 宮城県仙台市青葉区片平二丁目1番1号 2-1-1, Katahira, Aoba-ku, Sendai-shi, Miyagi 9808577, JP
Inventors:
照屋 健太 TERUYA, Kenta; JP
西澤 桂子 NISHIZAWA, Keiko; JP
堂浦 克美 DOH-URA, Katsumi; JP
Agent:
佐貫 伸一 SANUKI, Shinichi; JP
丹羽 武司 NIWA, Takeshi; JP
下田 俊明 SHIMODA, Toshiaki; JP
Priority Data:
2017-16931204.09.2017JP
Title (EN) PROPHYLACTIC OR THERAPEUTIC AGENT FOR CONFORMATIONAL DISEASES, AND SCREENING METHOD FOR CONFORMATIONAL DISEASE DRUGS
(FR) AGENT PROPHYLACTIQUE OU THÉRAPEUTIQUE POUR DES MALADIES CONFORMATIONNELLES, ET PROCÉDÉ DE CRIBLAGE POUR DES MÉDICAMENTS DE MALADIE CONFORMATIONNELLE
(JA) コンフォメーション病の予防又は治療剤、及びコンフォメーション病医薬のスクリーニング方法
Abstract:
(EN) The purpose of this invention is to provide a prophylactic or therapeutic agent for conformational diseases and a screening method for conformational disease drugs. Provided is a pharmaceutical composition for the prevention or treatment of conformational diseases, said composition comprising: an inactivated oligomeric protein that enables the prevention or treatment of a conformational disease and is obtained by crosslinking a plurality of abnormal proteins which cause said conformational disease; and a pharmaceutically-acceptable carrier.
(FR) L'objet de la présente invention est de fournir un agent prophylactique ou thérapeutique pour des maladies conformationnelles et un procédé de criblage pour des médicaments de maladie conformationnelle. L'invention concerne une composition pharmaceutique pour la prévention ou le traitement de maladies conformationnelles, ladite composition comprenant : une protéine oligomère inactivée qui permet la prévention ou le traitement d'une maladie conformationnelle et qui est obtenue par réticulation d'une pluralité de protéines anormales qui provoquent ladite maladie conformationnelle; l'invention concerne également un véhicule pharmaceutiquement acceptable.
(JA) コンフォメーション病の予防又は治療剤、及びコンフォメーション病医薬のスクリーニング方法を提供する。 コンフォメーション病を引き起こす複数の異常型タンパク質が、クロスリンクされた不活化オリゴマータンパク質を用いることで、コンフォメーション病の予防又は治療が可能となり、該不活化オリゴマータンパク質と、薬学的に許容される担体と、を含む、コンフォメーション病の予防又は治療のための医薬組成物が提供される。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)