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1. (WO2019045097) PH-SENSITIVE LIPOSOMES AND METHOD FOR PRODUCING SAME
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Pub. No.: WO/2019/045097 International Application No.: PCT/JP2018/032611
Publication Date: 07.03.2019 International Filing Date: 03.09.2018
IPC:
B01J 13/04 (2006.01) ,A61K 8/02 (2006.01) ,A61K 8/55 (2006.01) ,A61K 8/63 (2006.01) ,A61K 9/127 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13
Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02
Making microcapsules or microballoons
04
by physical processes, e.g. drying, spraying
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
02
characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
55
containing phosphorus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
63
Steroids; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
一丸ファルコス株式会社 ICHIMARU PHARCOS CO., LTD. [JP/JP]; 岐阜県本巣市浅木318番地1 318-1, Asagi, Motosu-shi, Gifu 5010475, JP
Inventors:
那波 慶彦 NAWA Yasuhiko; JP
Agent:
めぶき国際特許業務法人 MEBUKI IP LAW FIRM; 山梨県北杜市小淵沢町1037番地5 1037-5, Kobuchisawa-cho, Hokuto-shi, Yamanashi 4080044, JP
長谷川 洋 HASEGAWA, Hiroshi; JP
三宅 俊男 MIYAKE Toshio; JP
Priority Data:
2017-16935604.09.2017JP
2017-16935904.09.2017JP
Title (EN) PH-SENSITIVE LIPOSOMES AND METHOD FOR PRODUCING SAME
(FR) LIPOSOMES SENSIBLES AU PH ET LEUR PROCÉDÉ DE PRODUCTION
(JA) pH感受性リポソームおよびその製造方法
Abstract:
(EN) This method for producing pH-sensitive liposomes comprises: a step wherein a diol, a polyol having a valence of 3 or more and a liposome membrane-constituting component are mixed with each other under heating conditions, thereby preparing a mixture solution wherein the liposome membrane-constituting component is dissolved in a mixture of the diol and the polyol; a step wherein this mixture solution and an aqueous medium, which has been heated in advance, are mixed with each other and homogenized; a step wherein the homogenized aqueous medium is rapidly cooled, thereby producing liposomes; and a step wherein the produced liposomes are collected. This method according to the present invention stabilizes pH-sensitive liposomes, which have been unstable and thus hard to prepare in the past, and is thus able to prepare pH-sensitive liposomes by a simple process.
(FR) Ce procédé de production de liposomes sensibles au pH comprend : une étape dans laquelle un diol, un polyol ayant une valence de 3 ou plus et un composant constituant une membrane de liposome sont mélangés les uns avec les autres dans des conditions de chauffage, préparant ainsi une solution de mélange dans laquelle le composant constituant une membrane de liposome est dissous dans un mélange du diol et du polyol; une étape dans laquelle cette solution de mélange et un milieu aqueux, qui a été chauffé à l'avance, sont mélangés l'un à l'autre et homogénéisés; une étape dans laquelle le milieu aqueux homogénéisé est rapidement refroidi, produisant ainsi des liposomes; et une étape dans laquelle les liposomes produits sont collectés. Le procédé selon la présente invention stabilise des liposomes sensibles au pH, qui ont été instables et donc difficiles à préparer dans le passé, et est ainsi apte à préparer des liposomes sensibles au pH par un processus simple.
(JA) pH感受性リポソームの製造方法は、ジオールと、三価以上のポリオールと、リポソーム膜構成成分とを加温条件下に混合し、ジオールとポリオールとの混合物に、リポソーム膜構成成分を溶解した混合物溶液を調製する工程と、この混合物溶液と、あらかじめ加温した水性媒体とを混合し、これらを均質化する工程と、均質化された水性媒体を急冷し、リポソームを生成する工程と、生成したリポソームを回収する工程と、を含む。本発明の方法により、これまで不安定で調製が難しかったpH感受性リポソームを安定化し、簡便な方法によりpH感受性リポソームを調製することができる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)