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1. (WO2019045090) METHOD FOR PRODUCING INFLUENZA HA SPLIT VACCINE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/045090 International Application No.: PCT/JP2018/032537
Publication Date: 07.03.2019 International Filing Date: 03.09.2018
IPC:
A61K 39/145 (2006.01) ,C07K 14/11 (2006.01) ,C12N 15/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
11
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
31
Genes encoding microbial proteins, e.g. enterotoxins
33
Genes encoding viral proteins
40
Proteins from RNA viruses, e.g. flaviviruses
44
Orthomyxoviridae, e.g. influenza virus
Applicants:
公益財団法人ヒューマンサイエンス振興財団 JAPAN HEALTH SCIENCES FOUNDATION [JP/JP]; 東京都千代田区岩本町二丁目11番1号 11-1, Iwamoto-cho 2-chome, Chiyoda-ku, Tokyo 1010032, JP
Inventors:
高橋 宜聖 TAKAHASHI Yoshimasa; JP
安達 悠 ADACHI Yu; JP
阿戸 学 ATO Manabu; JP
Agent:
特許業務法人前田特許事務所 MAEDA & PARTNERS; 大阪府大阪市北区堂島浜1丁目2番1号 新ダイビル23階 Shin-Daibiru Bldg. 23F, 2-1, Dojimahama 1-chome, Kita-ku, Osaka-shi, Osaka 5300004, JP
Priority Data:
2017-16923004.09.2017JP
2018-13795223.07.2018JP
Title (EN) METHOD FOR PRODUCING INFLUENZA HA SPLIT VACCINE
(FR) PROCÉDÉ DE PRODUCTION D'UN VACCIN FRAGMENTÉ CONTRE L'HA DU VIRUS INFLUENZA
(JA) インフルエンザHAスプリットワクチンの製造方法
Abstract:
(EN) Provided is a method for producing an influenza HA split vaccine that produces antibodies that bind to the HA stem region of influenza, which is less likely to undergo antigenic mutation. Acid treatment of the influenza HA split vaccine is performed. An influenza HA split vaccine that produces antibodies that bind to LAH of the HA stem region is obtained by performing acid treatment. This influenza HA split vaccine has excellent protective ability against influenza virus infections of different antigenicity.
(FR) L'invention concerne un procédé de production d'un vaccin fragmenté contre l'HA du virus Influenza qui produit des anticorps qui se lient à la région tige de l'HA du virus Influenza, laquelle est moins susceptible de subir une mutation antigénique. Il est réalisé un traitement acide du vaccin fragmenté contre l'HA du virus Influenza. Un vaccin fragmenté contre l'HA du virus Influenza qui produit des anticorps qui se lient au LAH de la région tige de l'HA est obtenu en effectuant un traitement acide. Ce vaccin fragmenté contre l'HA du virus Influenza a une excellente capacité de protection contre les infections à virus Influenza de différentes antigénicités.
(JA) 抗原変異を起こしにくいインフルエンザのHA幹領域に結合する抗体を産生する、インフルエンザHAスプリットワクチンの製造方法を提供する。インフルエンザHAスプリットワクチンに酸性処理を施す。酸性処理を施すことにより、HA幹領域のLAHに結合する抗体を産生するインフルエンザHAスプリットワクチンが得られる。このインフルエンザHAスプリットワクチンは抗原性の異なる別のインフルエンザウイルス感染に対して優れた防御能を有する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)