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1. (WO2019045005) APPROPRIATE OSMOTIC PRESSURE RANGE OF SOLUTION CONTAINING DRUG EFFECTIVE IN LYMPHATIC DRUG DELIVERY SYSTEM
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Pub. No.: WO/2019/045005 International Application No.: PCT/JP2018/032220
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
A61K 47/26 (2006.01) ,A61K 9/08 (2006.01) ,A61K 31/282 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/704 (2006.01) ,A61K 31/7088 (2006.01) ,A61K 33/24 (2006.01) ,A61K 35/12 (2015.01) ,A61K 45/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
704
attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 宮城県仙台市青葉区片平二丁目1-1 1-1, Katahira 2-chome, Aoba-ku, Sendai-shi, Miyagi 9808577, JP
Inventors:
小玉 哲也 KODAMA, Tetsuya; JP
森 士朗 MORI, Shiro; JP
Agent:
特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; 東京都中央区日本橋人形町1丁目3番8号 沢の鶴人形町ビル Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013, JP
Priority Data:
2017-16795131.08.2017JP
Title (EN) APPROPRIATE OSMOTIC PRESSURE RANGE OF SOLUTION CONTAINING DRUG EFFECTIVE IN LYMPHATIC DRUG DELIVERY SYSTEM
(FR) PLAGE DE PRESSION OSMOTIQUE APPROPRIÉE D'UNE SOLUTION CONTENANT UN MÉDICAMENT EFFICACE DANS UN SYSTÈME D'ADMINISTRATION DE MÉDICAMENT POUR LE SYSTÈME LYMPHATIQUE
(JA) リンパ行性薬剤送達法に有効な薬剤を含む溶液の適正な浸透圧域
Abstract:
(EN) Provided is an optimum formulation for intralymphatic administration containing a drug such as a pharmaceutical, cell, or nucleic acid to be used in a lymphatic drug delivery system. A drug-containing liquid formulation for delivering the drug to a target lymph node by a lymphatic drug delivery system, wherein the formulation for intralymphatic administration has an osmotic pressure of the liquid of 700-2700 kPa.
(FR) L'invention concerne une formulation optimale pour une administration intralymphatique contenant un médicament tel qu'une substance pharmaceutique, des cellules ou des acides nucléiques, destinée à être utilisée dans un système d'administration de médicament pour le système lymphatique. L'invention concerne une formulation liquide contenant un médicament permettant d'administrer le médicament à un ganglion lymphatique cible par l'intermédiaire d'un système d'administration de médicament pour le système lymphatique, la formulation pour une administration intralymphatique ayant une pression osmotique du liquide comprise entre 700 et 2700 kPa.
(JA) リンパ行性薬剤送達法において用いられる、医薬、細胞、核酸等の薬剤を含有する最適なリンパ節内投与製剤を提供する。 リンパ行性薬剤送達法によって薬剤を標的リンパ節に送達するための薬剤含有液体製剤であって、液体の浸透圧が700~2700kPaであるリンパ節内投与製剤。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)