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1. (WO2019044952) METHOD FOR EVALUATING TREC OR KREC LEVEL, PARTICLES USED IN SAID METHOD, AND USE THEREOF
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Pub. No.: WO/2019/044952 International Application No.: PCT/JP2018/032063
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C12N 15/11 (2006.01) ,C12M 1/00 (2006.01) ,C12N 5/10 (2006.01) ,C12Q 1/6876 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
[IPC code unknown for C12Q 1/6876]
Applicants:
国立研究開発法人国立成育医療研究センター NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT [JP/JP]; 東京都世田谷区大蔵2-10-1 2-10-1, Okura, Setagaya-ku, Tokyo 1578535, JP
Inventors:
内山 徹 UCHIYAMA, Toru; JP
三浦 茜 MIURA, Akane; JP
小野寺 雅史 ONODERA, Masafumi; JP
峰岸 知子 MINEGISHI, Tomoko; JP
後藤 文洋 GOTO, Fumihiro; JP
諸田 沙織 MOROTA, Saori; JP
安藤 由希子 ANDO, Yukiko; JP
長田 香代 NAGATA, Kayo; JP
Agent:
特許業務法人HARAKENZO WORLD PATENT & TRADEMARK HARAKENZO WORLD PATENT & TRADEMARK; 大阪府大阪市北区天神橋2丁目北2番6号 大和南森町ビル Daiwa Minamimorimachi Building, 2-6, Tenjinbashi 2-chome Kita, Kita-ku, Osaka-shi, Osaka 5300041, JP
Priority Data:
2017-16615130.08.2017JP
Title (EN) METHOD FOR EVALUATING TREC OR KREC LEVEL, PARTICLES USED IN SAID METHOD, AND USE THEREOF
(FR) PROCÉDÉ POUR L'ÉVALUATION DU TAUX DE TREC OU DE KREC, PARTICULES UTILISÉES DANS LEDIT PROCÉDÉ, ET LEUR UTILISATION
(JA) TREC又はKRECの量を評価する方法、当該方法に用いる粒子、並びにこれらの利用
Abstract:
(EN) Provided are novel particles usable as control DNA or the like for evaluating the level of TREC and/or KREC at higher accuracy and the use of said particles. One embodiment of the present invention is particles in which a nucleic acid fragment of T-cell receptor excision circles (TREC) including a signal joint portion and/or a nucleic acid fragment of kappa-deleting receptor excision circles (KREC) including a signal joint portion is introduced into a cell or a liposome.
(FR) L'invention porte sur de nouvelles particules utilisables en tant qu'ADN témoin ou similaire pour l'évaluation du taux de TREC et/ou de KREC avec une précision plus élevée, et sur l'utilisation desdites particules. Un mode de réalisation de la présente invention concerne des particules dans lesquelles un fragment d'acide nucléique de cercles d'excision du récepteur des lymphocytes T (TREC) comprenant une partie de jonction de signal et/ou un fragment d'acide nucléique de cercles d'excision du récepteur de délétion kappa (KREC) comprenant une partie de jonction de signal sont introduits dans une cellule ou un liposome.
(JA) TREC及び/又はKRECの量の評価をより高精度で行うためのコントロールDNA等として使用可能な新規な粒子、及びその利用を提供する。本発明の一態様は、シグナルジョイント部分を含むTREC(T-cell Receptor Excision Circles)の核酸断片、及び、シグナルジョイント部分を含むKREC(Kappa-deleting Receptor Excision Circles)の核酸断片の少なくとも一方が、細胞内又はリポソーム内に導入されている、粒子である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)