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1. (WO2019044941) NOVEL COMPOUND HAVING THERAPEUTIC ACTIVITY AGAINST MYCOBACTERIUM AVIUM COMPLEX INFECTION, AND METHOD FOR PRODUCING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/044941 International Application No.: PCT/JP2018/032048
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C12P 17/16 (2006.01) ,A61K 31/7068 (2006.01) ,A61P 31/04 (2006.01) ,C07H 17/04 (2006.01) ,C12N 1/20 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
16
containing two or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
Applicants:
学校法人北里研究所 THE KITASATO INSTITUTE [JP/JP]; 東京都港区白金5丁目9番1号 9-1, Shirokane 5-chome, Minato-ku, Tokyo 1088641, JP
オーピーバイオファクトリー株式会社 OP BIO FACTORY CO., LTD. [JP/JP]; 沖縄県うるま市字州崎5番8 5-8, Aza Suzaki, Uruma-shi, Okinawa 9042234, JP
一般社団法人バイオ産業情報化コンソーシアム JAPAN BIOLOGICAL INFORMATICS CONSORTIUM [JP/JP]; 東京都江東区青海二丁目4番32号 4-32, Aomi 2-chome, Koto-ku, Tokyo 1358073, JP
Inventors:
供田 洋 TOMODA Hiroshi; JP
小山 信裕 KOYAMA Nobuhiro; JP
金本 昭彦 KANAMOTO Akihiko; JP
橋本 絢子 HASHIMOTO Junko; JP
小曽根 郁子 KOZONE Ikuko; JP
Agent:
特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES; 東京都港区愛宕二丁目5-1 愛宕グリーンヒルズMORIタワー32階 Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232, JP
Priority Data:
2017-16840401.09.2017JP
Title (EN) NOVEL COMPOUND HAVING THERAPEUTIC ACTIVITY AGAINST MYCOBACTERIUM AVIUM COMPLEX INFECTION, AND METHOD FOR PRODUCING SAME
(FR) NOUVEAU COMPOSÉ PRÉSENTANT UNE ACTIVITÉ THÉRAPEUTIQUE CONTRE UNE INFECTION PAR LE COMPLEXE MYCOBACTERIUM AVIUM ET PROCÉDÉ POUR SA PRODUCTION
(JA) マイコバクテリウム・アビウム複合感染症に対する治療活性を有する新規化合物及びその製造方法
Abstract:
(EN) The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structure different from those of known MAC infection therapeutics. One embodiment of the present invention pertains to a compound represented by formula (I) (wherein R1 is as defined in the description or the claims), a salt thereof, or a solvate of either. Another embodiment of the present invention pertains to a method for producing the compound represented by formula (I), a salt thereof, or a solvate of either; and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), the agent containing said compound, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either as an active ingredient.
(FR) L'objectif de la présente invention concerne un nouveau composé qui présente une activité antibactérienne contre Mycobacterium avium et Mycobacterium intracellulare, qui sont des agents pathogènes impliqués dans une infection par le MAC, et qui présente une structure de squelette différente de celles des agents thérapeutiques contre une infection par MAC connus. Un mode de réalisation de la présente invention concerne un composé représenté par la formule (I) (dans laquelle R1 est tel que défini dans la description ou dans les revendications), un sel correspondant ou un solvate de l'un ou de l'autre. Un autre mode de réalisation de la présente invention concerne un procédé de production du composé représenté par la formule (I), d'un sel correspondant ou d'un solvate de l'un ou l'autre; et un agent thérapeutique contre une infection par le complexe Mycobacterium avium (infection par MAC), l'agent contenant ledit composé, un sel pharmaceutiquement acceptable correspondant ou un solvate pharmaceutiquement acceptable de l'un ou l'autre en tant que principe actif.
(JA) 本発明は、MAC症の原因菌であるマイコバクテリウム・アビウム及びマイコバクテリウム・イントラセルラーレに対して抗菌活性を有し、且つ公知のMAC症の治療薬剤とは異なる骨格構造を有する新規化合物を提供することを課題とする。本発明の一態様は、式(I)[式中、R1は、明細書又は特許請求の範囲に記載の定義と同義である。]で表される化合物若しくはその塩、又はそれらの溶媒和物に関する。本発明の別の一態様は、式(I)で表される化合物若しくはその塩、又はそれらの溶媒和物の製造方法、並びに該化合物若しくはその製薬上許容される塩、又はそれらの製薬上許容される溶媒和物を有効成分として含む、マイコバクテリウム・アビウム(Mycobacterium avium)複合感染症(MAC症)に対する治療剤にも関する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)