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1. (WO2019044926) ANTI-HSV GB MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF
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Pub. No.: WO/2019/044926 International Application No.: PCT/JP2018/032019
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C12N 15/09 (2006.01) ,A61K 39/395 (2006.01) ,A61P 31/22 (2006.01) ,C07K 16/08 (2006.01) ,C07K 16/46 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01) ,C12P 21/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46
Hybrid immunoglobulins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
Applicants:
KMバイオロジクス株式会社 KM BIOLOGICS CO., LTD. [JP/JP]; 熊本県熊本市北区大窪一丁目6番1号 1-6-1 Okubo, Kita-ku, Kumamoto-shi, Kumamoto 8608568, JP
Inventors:
森 泰亮 MORI Hiroaki; JP
西村 知裕 NISHIMURA Tomohiro; JP
清水 裕之 SHIMIZU Hiroyuki; JP
河邉 昭博 KOUBE Akihiro; JP
Agent:
長谷川 芳樹 HASEGAWA Yoshiki; JP
清水 義憲 SHIMIZU Yoshinori; JP
Priority Data:
2017-16596830.08.2017JP
Title (EN) ANTI-HSV GB MONOCLONAL ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF
(FR) ANTICORPS MONOCLONAL CONTRE LA GB DU HSV OU FRAGMENT DE LIAISON À L'ANTIGÈNE CORRESPONDANT
(JA) 抗HSV gBモノクローナル抗体又はその抗原結合断片
Abstract:
(EN) An anti-HSV monoclonal antibody or an antigen-binding fragment thereof, which is an anti-HSV gB monoclonal antibody specifically binding to the envelope glycoprotein B (gB) of herpes simplex virus (HSV) or an antigen-binding fragment thereof, contains a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence represented by SEQ ID NO: 3, heavy chain CDR2 having the amino acid sequence represented by SEQ ID NO: 4 and heavy chain CDR3 having the amino acid sequence represented by SEQ ID NO: 5 and a light chain variable region comprising light chain CDR1 having the amino acid sequence represented by SEQ ID NO: 6, light chain CDR2 having the amino acid sequence represented by SEQ ID NO: 7 and light chain CDR3 having the amino acid sequence represented by SEQ ID NO: 8.
(FR) L'invention concerne un anticorps monoclonal anti-HSV, ou un fragment de liaison à l'antigène correspondant, cet anticorps étant un anticorps monoclonal contre la gB du HSV se liant spécifiquement à la glycoprotéine d'enveloppe B (gB) du virus Herpes simplex (HSV), ou un fragment de liaison à l'antigène correspondant, qui contient une région variable de chaîne lourde comprenant un CDR1 de chaîne lourde dont la séquence d'acides aminés est représentée par SEQ ID NO : 3, un CDR2 de chaîne lourde dont la séquence d'acides aminés est représentée par SEQ ID NO: 4 et un CDR3 de chaîne lourde dont la séquence d'acides aminés est représentée par SEQ ID NO : 5, ainsi qu'une région variable de chaîne légère comprenant un CDR1 de chaîne légère dont la séquence d'acides aminés est représentée par SEQ ID NO: 6, un CDR2 de chaîne légère dont la séquence d'acides aminés est représentée par SEQ ID NO : 7 et un CDR3 de chaîne légère dont la séquence d'acides aminés est représentée par SEQ ID NO : 8.
(JA) 抗HSVモノクローナル抗体又はその抗原結合断片は、単純ヘルペスウイルス(HSV)のエンベロープ糖タンパク質B(gB)に特異的に結合する、抗HSV gBモノクローナル抗体又はその抗原結合断片であって、配列番号3に記載のアミノ酸配列からなる重鎖CDR1、配列番号4に記載のアミノ酸配列からなる重鎖CDR2、及び配列番号5に記載のアミノ酸配列からなる重鎖CDR3を含む重鎖可変領域と、配列番号6に記載のアミノ酸配列からなる軽鎖CDR1、配列番号7に記載のアミノ酸配列からなる軽鎖CDR2、及び配列番号8に記載のアミノ酸配列からなる軽鎖CDR3を含む軽鎖可変領域とを含む。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)