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1. (WO2019044925) MODIFIED HSV GD PROTEIN AND VACCINE CONTAINING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/044925 International Application No.: PCT/JP2018/032018
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07K 14/035 (2006.01) ,A61K 39/245 (2006.01) ,A61P 31/22 (2006.01) ,A61P 37/04 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
035
Herpes simplex virus I or II
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
245
Herpetoviridae, e.g. herpes simplex virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
KMバイオロジクス株式会社 KM BIOLOGICS CO., LTD. [JP/JP]; 熊本県熊本市北区大窪一丁目6番1号 1-6-1 Okubo, Kita-ku, Kumamoto-shi, Kumamoto 8608568, JP
Inventors:
森 泰亮 MORI Hiroaki; JP
西村 知裕 NISHIMURA Tomohiro; JP
清水 裕之 SHIMIZU Hiroyuki; JP
河邉 昭博 KOUBE Akihiro; JP
片山 貴裕 KATAYAMA Takahiro; JP
Agent:
長谷川 芳樹 HASEGAWA Yoshiki; JP
清水 義憲 SHIMIZU Yoshinori; JP
Priority Data:
2017-16568130.08.2017JP
Title (EN) MODIFIED HSV GD PROTEIN AND VACCINE CONTAINING SAME
(FR) PROTÉINE HSV GD MODIFIÉE ET VACCIN LA CONTENANT
(JA) 改変型HSV gDタンパク質及びこれを含むワクチン
Abstract:
(EN) This modified HSV gD protein is a modified protein of a herpes simplex virus (HSV) envelope glycoprotein D (gD) wherein the modified HSV gD protein is modified so that at least one of the B cell epitopes (decotopes) having low or no neutralizing antibody-inducing activity does not function as an epitope as compared to B cell epitopes present in the receptor-binding domain (RBD) in the ectodomain of wild type HSV gD.
(FR) La présente invention concerne une protéine HSV gD modifiée qui est une protéine modifiée d'une glycoprotéine D (gD) d'enveloppe du virus de l'herpès simplex (HSV), la protéine HSV gD modifiée étant modifiée de sorte qu'au moins l'un des épitopes de lymphocytes B (decotopes) ayant une faible ou aucune activité inductrice d'anticorps neutralisant ne fonctionne pas en tant qu'épitope par comparaison avec des épitopes de lymphocytes B présents dans le domaine de liaison au récepteur (RBD) dans l'ectodomaine de HSV gD de type sauvage.
(JA) 本発明の改変型HSV gDタンパク質は、単純ヘルペスウイルス(HSV)のエンベロープ糖タンパク質D(gD)の改変タンパク質であって、野生型HSV gDのエクトドメイン(ectodomain)において、レセプター結合ドメイン(RBD)に存在するB細胞エピトープと比較して、中和抗体誘導活性が低い又は無いB細胞エピトープ(デコトープ)の少なくとも1つがエピトープとして機能しないように改変された、改変型HSV gDタンパク質である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)