Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019044894) CYCLIC PEPTIDE HAVING COLLAGEN BINDING ACTIVITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/044894 International Application No.: PCT/JP2018/031920
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07K 14/78 (2006.01) ,A61K 45/00 (2006.01) ,A61K 47/62 (2017.01) ,A61K 51/00 (2006.01) ,A61P 17/02 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/10 (2006.01) ,A61P 21/00 (2006.01) ,A61P 27/02 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/09 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
[IPC code unknown for A61K 47/62]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
02
for treating wounds, ulcers, burns, scars, keloids, or the like
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
Applicants:
学校法人早稲田大学 WASEDA UNIVERSITY [JP/JP]; 東京都新宿区戸塚町1丁目104番地 104 Totsukamachi 1-chome, Shinjuku-ku, Tokyo 1698050, JP
Inventors:
小出 隆規 KOIDE, Takaki; JP
瀧田 講 TAKITA, Koh; JP
平 和馬 TAIRA, Kazuma; JP
Agent:
牛木 護 USHIKI, Mamoru; JP
Priority Data:
2017-16668731.08.2017JP
Title (EN) CYCLIC PEPTIDE HAVING COLLAGEN BINDING ACTIVITY
(FR) PEPTIDE CYCLIQUE PRÉSENTANT UNE ACTIVITÉ DE LIAISON AU COLLAGÈNE
(JA) コラーゲンへの結合活性を有する環状ペプチド
Abstract:
(EN) The present invention addresses the problem of providing a compound having strong conjugating activity with respect to a modified collagen, a use of the compound as a modified collagen test drug and research reagent, and a composition containing the compound for diagnosing, preventing, or treating a disease that generates modified collagen, and is an agent-conjugated cyclic peptide, a salt thereof, or a solvate thereof, the agent-conjugated cyclic peptide having a repeating structure with 5 to 9 repetitions of tripeptide groups as repeating units comprising (Xaa-Yaa-Gly), the agent-conjugated cyclic peptide including two peptide chains which may include a linking group and may be the same or different, and the agent-conjugated cyclic peptide including a cyclic peptide group in which the vicinity of the N-terminus and the vicinity of the C-terminus of each peptide chain are cross-linked, and an agent being conjugated to a side chain of at least one amino acid residue of at least one peptide chain of the peptide chains.
(FR) La présente invention aborde le problème de l'obtention d'un composé présentant une forte activité de conjugaison par rapport à un collagène modifié, d'une utilisation du composé en tant que médicament d'essai de collagène modifié et réactif de recherche, et d'une composition contenant le composé pour diagnostiquer, prévenir ou traiter une maladie qui produit du collagène modifié. Le composé est un peptide cyclique conjugué à un agent, un sel correspondant ou un solvate correspondant, le peptide cyclique conjugué à un agent ayant une structure répétitive comprenant 5 à 9 répétitions de groupes tripeptidiques en tant que motifs de répétition dont (Xaa-Yaa-Gly), le peptide cyclique conjugué à un agent comprenant deux chaînes peptidiques qui peuvent comprendre un groupe de liaison et qui peuvent être identiques ou différentes, et le peptide cyclique conjugué à un agent comprenant un groupe de peptidique cyclique dans lequel le voisinage de l'extrémité N-terminale et le voisinage de l'extrémité C-terminale de chaque chaîne peptidique sont réticulés. Un agent est conjugué à une chaîne latérale d'au moins un résidu d'acide aminé d'au moins l'une des chaînes peptidiques.
(JA) 本発明は、変性コラーゲンに対して強い結合活性を有する化合物、該化合物の変性コラーゲンの検査薬及び研究用試薬としての使用、及び、該化合物を含有する変性コラーゲンを生じる疾患の診断用、又は予防若しくは治療用の組成物を提供することを課題とし、(Xaa-Yaa-Gly)からなるトリペプチド基を繰り返し単位として、5~9回の繰り返し構造を有し、連結基を含んでもよく、同一又は相違してもよいペプチド鎖の二本鎖を含み、各ペプチド鎖のN末端近傍及びC末端近傍が架橋された環状ペプチド基を含み、前記ペプチド鎖の少なくとも1方のペプチド鎖の少なくとも1つのアミノ酸残基の側鎖に薬剤基(agent)が結合(conjugate)している、薬剤結合環状ペプチド(agent-conjugated cyclic peptide)、又はその塩若しくは溶媒和物等を創製した。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)