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1. (WO2019044852) METHOD FOR DETERMINING SENSITIVITY TO SIDE EFFECTS OF RETINOIDS
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Pub. No.: WO/2019/044852 International Application No.: PCT/JP2018/031823
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
C12Q 1/6827 (2018.01) ,C12N 15/09 (2006.01) ,C12Q 1/6876 (2018.01)
[IPC code unknown for C12Q 1/6827]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
[IPC code unknown for C12Q 1/6876]
Applicants:
株式会社資生堂 SHISEIDO COMPANY, LTD. [JP/JP]; 東京都中央区銀座7丁目5番5号 5-5, Ginza 7-chome, Chuo-ku, Tokyo 1040061, JP
Inventors:
天野 聡 AMANO, Satoshi; JP
出田 立郎 IDETA, Ritsuro; JP
大田 正弘 OTA, Masahiro; JP
野村 宜史 NOMURA, Yoshifumi; JP
落合 美咲 OCHIAI, Misaki; JP
上沼 三紀子 KAMINUMA, Mikiko; JP
Agent:
青木 篤 AOKI, Atsushi; JP
三橋 真二 MITSUHASHI, Shinji; JP
渡辺 陽一 WATANABE, Yoichi; JP
中島 勝 NAKAJIMA, Masaru; JP
武居 良太郎 TAKEI, Ryotaro; JP
津田 英直 TSUDA, Hidenao; JP
Priority Data:
2017-16723031.08.2017JP
Title (EN) METHOD FOR DETERMINING SENSITIVITY TO SIDE EFFECTS OF RETINOIDS
(FR) PROCÉDÉ POUR DÉTERMINER LA SENSIBILITÉ AUX EFFETS SECONDAIRES DES RÉTINOÏDES
(JA) レチノイドの副作用に対する感受性の決定方法
Abstract:
(EN) Provided are a method for determining a subject's sensitivity to the side effects of retinoids on the basis of genetic elements by SNP analysis, a computer that determines sensitivity to the side effects of retinoids, and a program that controls the computer. There is a demand for the development of methods of mitigating sensitivity, beauty instruction services, and the development of cosmetic selection methods on the basis of a subject's determined sensitivity to the side effects of retinoids. Sensitivity to the side effects of retinoids can be determined on the basis of the detection of at least one SNP selected from the group consisting of the following: rs117761959、rs35515429、rs35736558、rs61840347、rs12754142、rs9290978、rs28501222、rs117675886、rs117758125、rs875705、rs58310152、rs58286474、rs112273273、rs73380909、rs73380910、rs73380913、rs12655922、rs17068781、rs278015、rs17068796、rs73381002、rs59490468、rs117142738、rs10086126、rs145653129、rs1903895、rs2574810、rs6480852、rs497578、rs562187、rs531402、rs2574801、rs2247887、rs2247880、rs814014、rs137908383、rs186198501、rs7933887、rs80067170、rs78606856、rs12100559、rs150171951、rs2060609、rs2060608、rs1349250、rs145745344、rs57595200、rs8008945、rs12907778、rs151092710、rs28363677、rs16948876、rs17753299、rs150302670, and rs763038.
(FR) L'invention concerne un procédé pour déterminer la sensibilité d'un sujet aux effets secondaires des rétinoïdes sur la base d'éléments génétiques par analyse de polymorphisme d'un seul nucléotide, un ordinateur qui détermine la sensibilité aux effets secondaires des rétinoïdes et un programme qui commande l'ordinateur. Il existe une demande pour la mise au point de procédés d'atténuation de la sensibilité, des services d'instruction de beauté, et pour la mise au point de procédés de sélection de produits cosmétiques sur la base d'une sensibilité déterminée d'un sujet aux effets secondaires des rétinoïdes. La sensibilité aux effets secondaires des rétinoïdes peut être déterminée sur la base de la détection d'au moins un polymorphisme d'un seul nucléotide choisi dans le groupe constitué des éléments suivants : rs117761959, rs35515429, rs35736558, rs61840347, rs12754142, rs9290978, rs28501222, rs117675886, rs117758125, rs875705, rs58310152, rs58286474, rs112273273, rs73380909, rs73380910, rs73380913, rs12655922, rs17068781, rs278015, rs17068796, rs73381002, rs59490468, rs117142738, rs10086126, rs145653129, rs1903895, rs2574810, rs6480852, rs497578, rs562187, rs531402, rs2574801, rs2247887, rs2247880, rs814014, rs137908383, rs186198501, rs7933887, rs80067170, rs78606856, rs12100559, rs150171951, rs2060609, rs2060608, rs1349250, rs145745344, rs57595200, rs8008945, rs12907778, rs151092710, rs28363677, rs16948876, rs17753299, rs150302670 et rs763038.
(JA) SNP解析により遺伝要素に基づいて対象のレチノイドの副作用に対する感受性を決定する方法、レチノイドの副作用に対する感受性を決定するコンピュータ、及び当該コンピュータを制御するプログラムの提供。決定された対象のレチノイドの副作用に対する感受性に基づいて、感受性を緩和する方法の開発、美容の指導サービス、化粧料の選択法の開発が求められている。以下の:rs117761959、rs35515429、rs35736558、rs61840347、rs12754142、rs9290978、rs28501222、rs117675886、rs117758125、rs875705、rs58310152、rs58286474、rs112273273、rs73380909、rs73380910、rs73380913、rs12655922、rs17068781、rs278015、rs17068796、rs73381002、rs59490468、rs117142738、rs10086126、rs145653129、rs1903895、rs2574810、rs6480852、rs497578、rs562187、rs531402、rs2574801、rs2247887、rs2247880、rs814014、rs137908383、rs186198501、rs7933887、rs80067170、rs78606856、rs12100559、rs150171951、rs2060609、rs2060608、rs1349250、rs145745344、rs57595200、rs8008945、rs12907778、rs151092710、rs28363677、rs16948876、rs17753299、rs150302670、及びrs763038からなる群から選ばれる、少なくとも1のSNPを検出することに基づいてレチノイドの副作用に対する感受性を決定することができる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)