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1. (WO2019044844) NOVEL Sin3 MODULATOR AND MEDICAL APPLICATION THEREOF
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Pub. No.: WO/2019/044844 International Application No.: PCT/JP2018/031791
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 45/00 (2006.01) ,A61K 31/5395 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/08 (2006.01) ,A61P 25/24 (2006.01) ,A61P 43/00 (2006.01) ,C07D 498/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5395
having two or more nitrogen atoms in the same ring, e.g. oxadiazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
08
Antiepileptics; Anticonvulsants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
株式会社PRISM BioLab PRISM BIOLAB CO., LTD. [JP/JP]; 神奈川県横浜市緑区長津田町4259-3 東工大横浜ベンチャープラザ Tokyo Tech, Yokohama Venture Plaza, 4259-3, Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 2268510, JP
Inventors:
橋本 均 HASHIMOTO, Hitoshi; JP
吾郷 由希夫 AGO, Yukio; JP
川瀬 啓生 KAWASE, Haruki; JP
小路 弘行 KOUJI, Hiroyuki; JP
三品 正 MISHINA, Tadashi; JP
河西 政次 KASAI, Masaji; JP
吉森 篤史 YOSHIMORI, Atsushi; JP
西村 善文 NISHIMURA, Yoshifumi; JP
栗田 順一 KURITA, Junichi; JP
平尾 優佳 HIRAO, Yuka; JP
Agent:
高島 一 TAKASHIMA, Hajime; JP
鎌田 光宜 KAMADA, Mitsunori; JP
Priority Data:
2017-16374128.08.2017JP
Title (EN) NOVEL Sin3 MODULATOR AND MEDICAL APPLICATION THEREOF
(FR) NOUVEAU MODULATEUR DE Sin3 ET SON APPLICATION MÉDICALE
(JA) 新規Sin3モジュレーター及びその医薬用途
Abstract:
(EN) The present invention provides a drug for the prevention and/or treatment of mental illness, the drug including as an active ingredient a Sin3 modulator, in particular the following compound or a pharmacologically acceptable salt thereof. This drug for the prevention and/or treatment of mental illness is especially useful in mental illnesses such as ASD, depression, and epilepsy.
(FR) La présente invention concerne un médicament pour la prévention et/ou le traitement de maladies mentales, le médicament comprenant comme principe actif un modulateur de Sin3, en particulier le composé décrit dans la description ou un sel pharmaceutiquement acceptable correspondant. Ce médicament pour la prévention et/ou le traitement de maladies mentales est particulièrement utile dans des maladies mentales telles que le TSA, la dépression et l'épilepsie.
(JA) 本発明は、Sin3モジュレーター、特に下記化合物又はその医薬上許容され得る塩を有効成分として含む精神疾患の予防及び/又は治療薬を提供する。本発明の精神疾患の予防及び/又は治療薬は、特にASD、うつ病及びてんかん等の精神疾患に有用である。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)