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1. (WO2019044266) PRODUCTION METHOD FOR PYRAZOLE-4-CARBOXAMIDE DERIVATIVE
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/044266 International Application No.: PCT/JP2018/027485
Publication Date: 07.03.2019 International Filing Date: 23.07.2018
IPC:
C07D 231/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applicants:
株式会社日本ファインケム JAPAN FINECHEM COMPANY, INC. [JP/JP]; 東京都千代田区内幸町1-3-2 内幸町東急ビル9階 Uchisaiwaicho Tokyu Bldg.9F, 3-2, Uchisaiwaicho 1-chome, Chiyoda-ku, Tokyo 1000011, JP
Inventors:
栗原 悠輔 KURIHARA, Yusuke; JP
佐藤 孝紀 SATO, Koki; JP
和須津 絢瀬 WASUZU, Ayase; JP
山田 裕 YAMADA, Yu; JP
Agent:
大谷 保 OHTANI, Tamotsu; JP
平澤 賢一 HIRASAWA, Kenichi; JP
Priority Data:
2017-16373028.08.2017JP
Title (EN) PRODUCTION METHOD FOR PYRAZOLE-4-CARBOXAMIDE DERIVATIVE
(FR) PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ DE PYRAZOLE-4-CARBOXAMIDE
(JA) ピラゾール-4-カルボキサミド誘導体の製造方法
Abstract:
(EN) A method for producing a pyrazole-4-carboxamide derivative by subjecting a pyrazole-4-carboxylic acid ester and an amine to an aminolysis reaction in a solvent in the presence of a base, the method being characterized in that the reaction is completed without removing the by-product alcohol or phenol from the system. The method is for industrially producing the pyrazole-4-carboxamide derivative, which is useful as an agricultural bactericide, and can produce said derivative having a higher purity more easily in higher yield than conventional methods.
(FR) L'invention concerne un procédé de production d'un dérivé de pyrazole-4-carboxamide par soumission d'un ester d'acide pyrazole-4-carboxylique et d'une amine à une réaction d'aminolyse dans un solvant en présence d'une base, le procédé étant caractérisé en ce que la réaction est achevée sans retirer l'alcool de sous-produit ou le phénol du système. Le procédé de la présente invention est destiné à la production industrielle du dérivé de pyrazole-4-carboxamide, qui est utile en tant que bactéricide agricole, et peut produire ledit dérivé avec une pureté plus élevée, de manière plus facile, avec un rendement plus élevé que les procédés classiques.
(JA) ピラゾール-4-カルボン酸エステルとアミンとを、溶媒中で塩基の存在下にアミノリシス反応を行いピラゾール-4-カルボキサミド誘導体を得る際に、副生するアルコール又はフェノールを系外に除去することなく反応を完結させることを特徴とするピラゾール-4-カルボキサミド誘導体の製造方法。農業用殺菌剤として有用なピラゾール-4-カルボキサミド誘導体を従来の方法に比べて簡便且つ高収率、高純度で得ることが出来る工業的な製造方法が提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)