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1. (WO2019043724) PROCESSES FOR THE PREPARATION OF (S)-2-(2-(BENZOFURAN-6-CARBONYL)-5,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXAMIDO)-3-(3-(METHYLSULFONYL)PHENYL) PROPANOIC ACID AND POLYMORPHS THEREOF
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Pub. No.: WO/2019/043724 International Application No.: PCT/IN2018/050552
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
Applicants:
SRINIVASAN, Thirumalai Rajan [IN/IN]; IN
MSN LABORATORIES PRIVATE LIMITED, R&D CENTER [IN/IN]; Plot No. 12, Phase-IV, Sy No. 119 to 140, 258, 275 to 280, IDA, Pashamylaram (Vill), Patancheru (Mdl), Sangareddy (Dist), Telangana (State) Hyderabad 502307, IN
Inventors:
SRINIVASAN, Thirumalai Rajan; IN
SAJJA, Eswaraiah; IN
GHOJALA, Venkat Reddy; IN
SAGYAM, Rajeshwar Reddy; IN
RANGINENI, Srinivasulu; IN
KOMMERA, Rajashekar; IN
Common
Representative:
SRINIVASAN, Thirumalai Rajan; IN
Priority Data:
20174103029228.08.2017IN
20174104173922.11.2017IN
20184100487508.02.2018IN
20184101994728.05.2018IN
Title (EN) PROCESSES FOR THE PREPARATION OF (S)-2-(2-(BENZOFURAN-6-CARBONYL)-5,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXAMIDO)-3-(3-(METHYLSULFONYL)PHENYL) PROPANOIC ACID AND POLYMORPHS THEREOF
(FR) PROCÉDÉS POUR LA PRÉPARATION DE L'ACIDE (S)-2-(2-(BENZOFURAN-6-CARBONYL)-5,7-DICHLORO-1,2,3,4-TÉTRAHYDROISOQUINOLÉINE-6-CARBOXAMIDO)-3-(3-(MÉTHYLSULFONYL)PHÉNYL)PROPANOÏQUE ET DE POLYMORPHES DE CELUI-CI
Abstract:
(EN) The present invention relates to various processes for the preparation of (S)-2-(2- (benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3- (methylsulfonyl)phenyl)propanoic acid represented by the following structural formula-1. The said processes for the preparation of compound of formula-1 proceed through various novel intermediate compounds. The present invention also relates to novel crystalline polymorphs of compound of formula-1 and processes for preparation thereof.
(FR) La présente invention concerne divers procédés pour la préparation de l'acide (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tétrahydroisoquinoléine-6-carboxamido)-3-(3-(méthylsulfonyl)phényl)propanoïque représenté par la formule développée 1 suivante. Lesdits procédés pour la préparation du composé de formule 1 procèdent de manière à utiliser divers nouveaux composés intermédiaires. La présente invention concerne également de nouveaux polymorphes cristallins du composé de formule 1 et des procédés pour la préparation de ceux-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)