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1. WO2019043701 - CORE-SHELL PARTICLES COMPRISING METAL OXIDE AND LANTHANIDE ELEMENT

Publication Number WO/2019/043701
Publication Date 07.03.2019
International Application No. PCT/IL2018/050951
International Filing Date 28.08.2018
IPC
A61K 33/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/155 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C01G 49/02 2006.01
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
GCOMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F94
49Compounds of iron
02Oxides; Hydroxides
A61K 31/7105 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
CPC
A61K 31/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
A61K 33/244
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
244Lanthanides; Compounds thereof
A61K 33/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
A61K 47/6923
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6921the form being a particulate, a powder, an adsorbate, a bead or a sphere
6923the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Applicants
  • BAR-ILAN UNIVERSITY [IL]/[IL]
Inventors
  • LELLOUCHE, Jean Paul
  • MICHAELI, Shulamit
  • ISRAEL, Limor liron
  • HAREL, Yifat
  • DOLITZKY, Avishay
  • OSTROVSKY, Stella
Agents
  • KESTEN, Dov
  • GEYRA, Assaf
  • GASSNER, Dvir
Priority Data
62/550,72628.08.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CORE-SHELL PARTICLES COMPRISING METAL OXIDE AND LANTHANIDE ELEMENT
(FR) PARTICULES NOYAU-ENVELOPPE COMPRENANT UN OXYDE MÉTALLIQUE ET UN ÉLÉMENT LANTHANIDE
Abstract
(EN)
A composition comprised of one or more particles, having a core comprised of metal oxide, and a shell comprised of a cationic lanthanide element, wherein the lanthanide element has linked thereto a polymer and an active agent. Further disclosed herein are methods for treatment and diagnosis of a disease or a disorder e.g., an inflammatory disease, cancer, or a neurodegenerative disorder.
(FR)
L'invention concerne une composition comprenant une ou plusieurs particules, comportant un noyau constitué d'oxyde métallique, et une enveloppe constituée d'un élément lanthanide cationique, un polymère et un agent actif étant liés à l'élément lanthanide. L'invention concerne en outre des méthodes pour le traitement et le diagnostic d'une maladie ou d'un trouble, par exemple d'une maladie inflammatoire, d'un cancer ou d'un trouble neurodégénératif.
Also published as
Latest bibliographic data on file with the International Bureau