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1. (WO2019043701) CORE-SHELL PARTICLES COMPRISING METAL OXIDE AND LANTHANIDE ELEMENT
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Pub. No.: WO/2019/043701 International Application No.: PCT/IL2018/050951
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 33/26 (2006.01) ,A61K 9/14 (2006.01) ,A61K 31/155 (2006.01) ,B82Y 5/00 (2011.01) ,C01G 49/02 (2006.01) ,A61K 31/7105 (2006.01) ,A61K 38/00 (2006.01) ,C12N 15/113 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
26
Iron; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
C CHEMISTRY; METALLURGY
01
INORGANIC CHEMISTRY
G
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F94
49
Compounds of iron
02
Oxides; Hydroxides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
BAR-ILAN UNIVERSITY [IL/IL]; 5290002 Ramat Gan, IL
Inventors:
LELLOUCHE, Jean Paul; IL
MICHAELI, Shulamit; IL
ISRAEL, Limor liron; IL
HAREL, Yifat; IL
DOLITZKY, Avishay; IL
OSTROVSKY, Stella; IL
Agent:
KESTEN, Dov; IL
GEYRA, Assaf; IL
GASSNER, Dvir; IL
Priority Data:
62/550,72628.08.2017US
Title (EN) CORE-SHELL PARTICLES COMPRISING METAL OXIDE AND LANTHANIDE ELEMENT
(FR) PARTICULES NOYAU-ENVELOPPE COMPRENANT UN OXYDE MÉTALLIQUE ET UN ÉLÉMENT LANTHANIDE
Abstract:
(EN) A composition comprised of one or more particles, having a core comprised of metal oxide, and a shell comprised of a cationic lanthanide element, wherein the lanthanide element has linked thereto a polymer and an active agent. Further disclosed herein are methods for treatment and diagnosis of a disease or a disorder e.g., an inflammatory disease, cancer, or a neurodegenerative disorder.
(FR) L'invention concerne une composition comprenant une ou plusieurs particules, comportant un noyau constitué d'oxyde métallique, et une enveloppe constituée d'un élément lanthanide cationique, un polymère et un agent actif étant liés à l'élément lanthanide. L'invention concerne en outre des méthodes pour le traitement et le diagnostic d'une maladie ou d'un trouble, par exemple d'une maladie inflammatoire, d'un cancer ou d'un trouble neurodégénératif.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)