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1. (WO2019043635) D-AMINO ACID OXIDASE ACTIVITY INHIBITING COMPOUNDS
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Pub. No.: WO/2019/043635 International Application No.: PCT/IB2018/056660
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07D 471/04 (2006.01) ,A61P 25/00 (2006.01) ,A61K 31/44 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
Applicants:
RICHTER GEDEON NYRT. [HU/HU]; Gyömröi út 19-21. 1103 Budapest, HU
ORION CORPORATION [FI/FI]; Orionintie 1 02200 Espoo, FI
Inventors:
HAIKARAINEN, Anssi; FI
JOUBERT, Muriel; FI
KÁROLYI, Benedek; HU
KÄSNÄNEN, Heikki; FI
PASSINIEMI, Mikko; FI
POHJAKALLIO, Antti; FI
SZÁNTÓ, Gábor; HU
VAISMAA, Matti; FI
Priority Data:
2017578901.09.2017FI
Title (EN) D-AMINO ACID OXIDASE ACTIVITY INHIBITING COMPOUNDS
(FR) COMPOSÉS INHIBITEURS DE L'ACTIVITÉ DE D-AMINO ACIDE OXYDASE
Abstract:
(EN) Compounds of formula (I), wherein R1 through R3 are as defined in the claims, or pharmaceutically acceptable esters, salts, hydrates or solvates thereof, useful as DAAO inhibitors as well as pharmaceutical compositions containing them and their use as modulators of DAAO activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject are provided.
(FR) La présente invention concerne des composés de formule (I), dans laquelle R1 à R3 sont tels que définis dans les revendications, ou des esters, des sels, des hydrates ou des solvates pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'inhibiteurs de DAAO, ainsi que des compositions pharmaceutiques les contenant et leur utilisation en tant que modulateurs de l'activité de DAAO, des taux de D-sérine, des produits d'oxydation de D-sérine et une activité du récepteur de NMDA dans le système nerveux d'un sujet mammifère.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)