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1. (WO2019043593) NUCLEIC ACID ENCODING CRM197 AND PROCESS FOR IMPROVED EXPRESSION THEREOF
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Pub. No.: WO/2019/043593 International Application No.: PCT/IB2018/056586
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07K 14/34 (2006.01) ,C12N 15/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
34
from Corynebacterium (G)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants:
LORVEN BIOLOGICS PRIVATE LIMITED [IN/IN]; Modugulapeta Village, Govindapuram Post, Santhakaviti Mandal Srikakulam District, Andhra Pradesh 532123, IN
Inventors:
PUPPALA, Lavanya; IN
MUDILI, Venkataramana; IN
Agent:
BHATTACHARYYA, Goutam; IN
MANICKAM, Devi Sundaramurthy; IN
JONNALAGADDA, Naresh Kumar; IN
GANGULY, Samrat; IN
A, Yamuna; IN
Priority Data:
20174103114001.09.2017IN
Title (EN) NUCLEIC ACID ENCODING CRM197 AND PROCESS FOR IMPROVED EXPRESSION THEREOF
(FR) ACIDE NUCLÉIQUE CODANT POUR CRM197 ET PROCESSUS D'EXPRESSION AMÉLIORÉE DE CELUI-CI
Abstract:
(EN) The present invention provides for a nucleic acid encoding CRM197 protein and process for improved expression of CRM197 protein. The invention represents an advancement in the field of genetic engineering and discloses a modified nucleic acid for achieving optimum expression of CRM197 protein in a heterologous host. The invention also discloses vectors carrying the modified nucleic acid and recombinant host cells carrying the vectors. The invention also discloses the process for producing a recombinant host cell, process for production of the recombinant protein and an improved down streaming process.
(FR) La présente invention concerne un acide nucléique codant pour la protéine CRM197 et un processus d'expression améliorée de la protéine CRM197. L'invention représente une avancée dans le domaine de l'ingénierie génétique et concerne un acide nucléique modifié permettant d'obtenir une expression optimale de la protéine CRM197 dans un hôte hétérologue. L'invention concerne également des vecteurs portant l'acide nucléique modifié et des cellules hôtes recombinantes portant les vecteurs. L'invention concerne également le processus de production d'une cellule hôte recombinante, un processus de production de la protéine recombinante et un processus en aval amélioré.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)