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1. (WO2019043587) A PROCESS FOR THE PREPARATION OF TREOSULFAN
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Pub. No.: WO/2019/043587 International Application No.: PCT/IB2018/056573
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07C 309/68 (2006.01) ,C07D 317/18 (2006.01) ,C07D 317/32 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
309
Sulfonic acids; Halides, esters, or anhydrides thereof
63
Esters of sulfonic acids
64
having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
68
of a carbon skeleton substituted by singly-bound oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
18
Radicals substituted by singly bound oxygen or sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
FRESENIUS KABI ONCOLOGY LTD. [IN/IN]; B-310, Som Dutt Chambers-1, Bhikaji Cama Place New Delhi 110066, IN
Inventors:
SHARMA, Ashwani Kumar; IN
UPADHYAY, Saurabh; IN
DUA, Heena; IN
MUSMADE, Sachin; IN
SINGH, Govind; IN
LAHIRI, Saswata; IN
CABRI, Walter; IT
Priority Data:
IN20171103081331.08.2017IN
Title (EN) A PROCESS FOR THE PREPARATION OF TREOSULFAN
(FR) PROCÉDÉ DE PRÉPARATION DE TRÉOSULFAN
Abstract:
(EN) The present invention relates to a process for the preparation of Treosulfan using sodium borohydride and iodine as reducing agent, which is less hazardous and convenient as compared to the reagents used in the prior art. The invention also relates to a novel intermediate to obtain Treosulfan in high yield and high purity.
(FR) La présente invention concerne un procédé de préparation de tréosulfan au moyen de borohydrure de sodium et d’iode en tant qu’agent réducteur, qui est moins dangereux et pratique par rapport aux réactifs utilisés dans l’art antérieur. L’invention concerne en outre un nouvel intermédiaire pour obtenir du tréosulfan à un rendement élevé et une pureté élevée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)