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1. (WO2019043427) FAST SELF DISPERSIBLE DOSAGE FORMS OF DEFERASIROX
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Pub. No.: WO/2019/043427 International Application No.: PCT/IB2017/001201
Publication Date: 07.03.2019 International Filing Date: 01.09.2017
IPC:
A61K 9/46 (2006.01) ,A61K 9/00 (2006.01) ,A61K 9/20 (2006.01) ,A61K 31/4196 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
46
effervescent
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
Applicants:
SHAHIN, Asaad [JO/JO]; JO
JORDAN SWEDEN MEDICAL AND STERILIZATION COMPANY [JO/JO]; 69, Saeed Al-Mufti St. Sweifyeh P.O. Box 851831 Amman 11185, JO
Inventors:
SHAHIN, Asaad; JO
Priority Data:
Title (EN) FAST SELF DISPERSIBLE DOSAGE FORMS OF DEFERASIROX
(FR) FORMES POSOLOGIQUES À AUTO-DISPERSION RAPIDE DE DÉFÉRASIROX
Abstract:
(EN) The present invention relates to a pharmaceutical composition comprising a poorly water soluble active pharmaceutical ingredient (API) (such as the iron chelator deferasirox) or a pharmaceutically acceptable salt thereof, and at least two pharmaceutically acceptable excipients. The present invention further relates to a method for the preparation thereof and an use thereof for treatment and/or methods of treatment administering the pharmaceutical composition, wherein the treatment is for treating iron overload in transfusion dependent anemias (transfusion hemosiderosis), in particular thalassemia major, thalassemia intermediate, and in sickle cell disease, to reduce iron-related morbidity and mortality, in patients 2 years and older.
(FR) La présente invention concerne une composition pharmaceutique comprenant un principe actif pharmaceutique (API) faiblement hydrosoluble (tel que le chélateur du fer déférasirox) ou un sel pharmaceutiquement acceptable correspondant, et au moins deux excipients pharmaceutiquement acceptables. La présente invention concerne en outre un procédé de préparation de ladite composition et une utilisation de cette dernière pour le traitement et/ou des méthodes de traitement consistant à administrer la composition pharmaceutique, le traitement étant destiné à traiter la surcharge en fer observée dans les anémies liées à des transfusions (hémosidérose transfusionnelle), en particulier la thalassémie majeure et la thalassémie intermédiaire, et dans la drépanocytose, afin de diminuer la morbidité et la mortalité liées au fer, chez les patients âgés d'au moins 2 ans.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)