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1. (WO2019043417) CYTOTOXIC AGENTS
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Pub. No.: WO/2019/043417 International Application No.: PCT/GB2018/052501
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
C07D 519/00 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/5513 (2006.01) ,A61K 47/50 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
5513
1,4-Benzodiazepines, e.g. diazepam
[IPC code unknown for A61K 47/50]
Applicants:
FEMTOGENIX LIMITED [GB/GB]; BioPark Broadwater Road Welwyn Garden City Hertfordshire AL7 3AX, GB
Inventors:
JACKSON, Paul Joseph Mark; GB
THURSTON, David Edwin; GB
RAHMAN, Khondaker Mirazur; GB
Agent:
SCRIPT IP LIMITED; Turnpike House 18 Bridge Street FROME Somerset BA11 1BB, GB
SIMCOX, Michael Thomas; GB
Priority Data:
1714115.104.09.2017GB
Title (EN) CYTOTOXIC AGENTS
(FR) AGENTS CYTOTOXIQUES
Abstract:
(EN) The invention relates to a compound of formula (I) or formula (II) or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate and in the treatment of proliferative diseases.
(FR) L'invention concerne un composé de formule (I) ou de formule (II) ou des sels pharmaceutiquement acceptables, des solvates, des tautomères, des stéréoisomères ou des mélanges de ceux-ci ; qui sont utiles en tant que médicaments, en particulier en tant qu'agents anti-prolifératifs et pour une utilisation en tant que médicament dans un conjugué anticorps-médicament ainsi que dans le traitement de maladies prolifératives.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)