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1. (WO2019043389) TREATMENT OF CANCER BY STIMULATION OF IL-12 PRODUCTION
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Pub. No.: WO/2019/043389 International Application No.: PCT/GB2018/052448
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
A61K 31/4412 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4412
having oxo groups directly attached to the heterocyclic ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
MACROPHAGE PHARMA LIMITED [GB/GB]; St. Stephens House Arthur Road Windsor Berkshire SL4 1RU, GB
Inventors:
MOFFAT, David Festus Charles; GB
PERRY, Martin John; GB
ANDERTON, Stephen Mark; GB
DORIS, Clare Louise; GB
Agent:
SIMONS, Amanda Louise; GB
Priority Data:
1713975.931.08.2017GB
Title (EN) TREATMENT OF CANCER BY STIMULATION OF IL-12 PRODUCTION
(FR) TRAITEMENT DU CANCER PAR STIMULATION DE LA PRODUCTION D'IL-12
Abstract:
(EN) The present invention relates to a compound and composition for use in the stimulation of IL-12 production and IFN-γ production, which compound is selected from: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5- difluorophenyl}ethyl)-L-alaninate, or a pharmaceutically acceptable salt, hydrate or solvate thereof; and N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5- difluorophenyl}ethyl)-L-alanine.
(FR) La présente invention concerne un composé et une composition destinés à être utilisés dans la stimulation de la production d'IL-12 et de la production d'IFN-γ, ledit composé étant sélectionné parmi : le tert-butyl N-[2-{4- [6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridine-1(2H)-yl]-3,5-difluorophényl}éthyl)-L-alaninate, ou un sel hydrate ou solvate pharmaceutiquement acceptable correspondant ; et la N-[2- {4-[6-amino-5-(2,4-difluorobenzoyle))-2-oxopyridine-1(2H)-yl]-3,5-difluorophényl}éthyl)-L-alanine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)