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1. (WO2019043386) Combination therapy
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Pub. No.: WO/2019/043386 International Application No.: PCT/GB2018/052445
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
A61K 31/7068 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/282 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
28
Compounds containing heavy metals
282
Platinum compounds
Applicants:
NUCANA PLC [GB/GB]; 3 Lochside Way Edinburgh Scotland EH12 9DT, GB
Inventors:
GRIFFITH, Hugh; GB
Agent:
HGF LIMITED; 1 City Walk Leeds West Yorkshire LS11 9DX, GB
Priority Data:
1713914.830.08.2017GB
Title (EN) Combination therapy
(FR) POLYTHÉRAPIE
Abstract:
(EN) This invention relates to a combination of 2'-Deoxy-2',2'-difluoro-D-cytidine-5'-O-[phenyl (benzoxy-L-alaninyl)] phosphate)(NUC-1031) and carboplatin, or other forms of platinum, and the use of the combination in treating cancer patients selected based on the patient's cancer's response to platinum. In particular the invention concerns the treatment of patients that have platinum sensitive cancers or platinum partially sensitive cancers.
(FR) Cette invention concerne une association de 2'-désoxy-2',2'-difluoro-D-cytidine-5'-O-[phényl(benzoxy-L-alaninyl)]phosphate) (NUC-1031) et de carboplatine, ou autres formes de platine, et l'utilisation de cette association dans le traitement de patients atteints de cancer choisis sur la base de la réponse du cancer du patient au platine. En particulier, l'invention concerne le traitement de patients ayant des cancers sensibles au platine ou des cancers partiellement sensibles au platine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)