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1. (WO2019043375) PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Pub. No.: WO/2019/043375 International Application No.: PCT/GB2018/052432
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
A61K 31/105 (2006.01) ,A61P 11/00 (2006.01) ,A61P 11/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
095
Sulfur, selenium or tellurium compounds, e.g. thiols
105
Persulfides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
02
Nasal agents, e.g. decongestants
Applicants:
NEEM BIOTECH LIMITED [GB/GB]; Units G&H Roseheyworth Business Park Abertillery Gwent NP13 1SX, GB
Inventors:
GRAZ, Carl Jorg Michael; GB
SYKES, Lucy Helen; GB
Agent:
GILL, Siân; GB
ANDERSON, Oliver; GB
BEASLEY, Benjamin; GB
BROWN, Alexander; GB
CHETTLE, John; GB
CLARK, Jonathan; GB
COLONNA, Matthew; GB
CORK, Robert; GB
DAINTY, Katherine; GB
DERRY, Paul; GB
DUNLEAVY, Christopher; GB
ELEND, Almut; GB
FLETCHER, Scott; GB
GILANI, Anwar; GB
GREY, Ian; GB
HANDLEY, Matthew; GB
HARRISON, Philip; GB
HEWETT, Jonathan; GB
HUDSON, George; GB
HUTTER, Anton; GB
JOHNSON, Stephen; GB
JUMP, Timothy; GB
KATHRYN MCNAMARA; Venner Shipley LLP 200 Aldersgate London EC1A 4HD, GB
KENNEDY, Richard; GB
LEANSE, Thomas; GB
MAYS, Julie; GB
NEWCOMBE, Christopher; GB
MCDOUGALL, James; GB
PETTY, Catrin; GB
PIOTROWICZ, Pawel; GB
ROGAN, Jack; GB
RUSSELL, Tim; GB
SAYER, Robert; GB
SHELTON, Ruth; GB
TAOR, Simon; GB
THORNILEY, Peter; GB
WALASKI, Jan; GB
WHITING, Gary; GB
Priority Data:
1713920.530.08.2017GB
Title (EN) PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
(FR) COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS
Abstract:
(EN) The present invention relates to the use of ajoene, analogues and derivatives thereof to regulate sodium absorption and fluid homeostasis and to treat disorders with symptoms related to elevated sodium transport and difficulties associated with mucociliary clearance. The invention provides pharmaceutical compositions comprising ajoene or an analogue or derivative thereof, for reducing sodium ion uptake in cells. This may be achieved by modulating the activity of an epithelial sodium channel (ENa C) and/or a Na+/K+ - ATPase.
(FR) La présente invention concerne l'utilisation d'ajoène, d'analogues et de dérivés de celui-ci pour réguler l'absorption de sodium et l'homéostasie de fluide et pour traiter des troubles ayant des symptômes liés à un transport de sodium élevé et des difficultés associées à une clairance mucociliaire. L'invention concerne des compositions pharmaceutiques comprenant de l'ajoène ou un analogue ou un dérivé de celui-ci, pour réduire l'absorption des ions sodium dans les cellules. Ceci peut être obtenu par modulation de l'activité d'un canal sodique épithélial (ENa C) et/ou d'une Na+/K+-ATPase.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)