Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019043282) COMBINED PRODUCT COMPRISING A MODIFIED MESENCHYMAL STEM CELL AND AN ANTIGENIC SUBSTANCE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/043282 International Application No.: PCT/ES2018/070582
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
C12N 5/077 (2010.01) ,C12N 5/0775 (2010.01) ,A61K 35/12 (2015.01) ,A61K 35/28 (2015.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
Applicants:
INSTITUTO DE SALUD CARLOS III [ES/ES]; Avenida de Monforte de Lemos, 5 28029 Madrid, ES
Inventors:
GARCÍA CASTRO, Javier; ES
CEJALVO GOYANES, Teresa; ES
PERISÉ BARRIOS, Ana Judith; ES
GAMBERA, Stefano; ES
MORALES MOLINA, Álvaro; ES
Agent:
FUSTER, Gustavo; ES
Priority Data:
P20173106604.09.2017ES
Title (EN) COMBINED PRODUCT COMPRISING A MODIFIED MESENCHYMAL STEM CELL AND AN ANTIGENIC SUBSTANCE
(FR) PRODUIT DE COMBINAISON COMPRENANT UNE CELLULE SOUCHE MÉSENCHYMATEUSE MODIFIÉE ET UNE SUBSTANCE ANTIGÈNE
(ES) PRODUCTO DE COMBINACIÓN QUE COMPRENDE UNA CÉLULA MADRE MESENQUIMAL MODIFICADA Y UNA SUSTANCIA ANTIGÉNICA
Abstract:
(EN) The present application discloses a combined product for the treatment of cancer. The combined product comprises (i) a modified mesenchymal stem cell, and (ii) an antigenic substance. Moreover, the present application also provided a method for producing a modified mesenchymal stem cell comprising an intracellular parasite and a kit comprising (a) a mesenchymal stem cell, (b) an antigenic substance and (c) an inhibitor for a receptor of the Toll-like type and/or an inhibitor of the gene MyD88.
(FR) La présente invention concerne un produit de combinaison pour le traitement de cancer. Le produit de combinaison comprend (i) une cellule souche mésenchymateuse modifiée, et (ii) une substance antigène. En outre, ladite invention concerne aussi une méthode de production d'une cellule souche mésenchymateuse modifiée comprenant un parasite intracellulaire et un kit comprenant (a) une cellule souche mésenchymateuse, (b) une substance antigène, et (c) un inhibiteur du récepteur de type Toll-like et/ou du gène MyD88.
(ES) La presente solicitud proporciona un producto de combinación para el tratamiento de cáncer. El producto de combinación comprende (i) una célula madre mesenquimal modificada, y (ii) una sustancia antigénica. Además,la presente solicitud también proporciona un método para la producción de una célula madre mesenquimal modificada que comprende un parásito intracelular y un kit que comprende (a) una célula madre mesenquimal, (b) una sustancia antigénica y (c) un inhibidor del receptor de tipo Toll-like y/o del gen MyD88.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)