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1. (WO2019043279) COMPOSITIONS ABLE TO MODULATE THE STIMULATION OF ENDOGENOUS GDNF FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
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Pub. No.: WO/2019/043279 International Application No.: PCT/ES2018/070577
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07K 14/705 (2006.01) ,C12N 15/12 (2006.01) ,A61P 25/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
Applicants:
SERVICIO ANDALUZ DE SALUD [ES/ES]; Avenida de la Constitución, 18 41071 Sevilla, ES
UNIVERSIDAD DE SEVILLA [ES/ES]; Pabellón de Brasil, Pº de las Delicias s/n 41013 Sevilla, ES
Inventors:
LÓPEZ BARNEO, José; ES
DÁNGLEMONT DE TASSIGNY, Xavier; ES
ENTERRÍA MORALES, Daniel; ES
LÓPEZ LÓPEZ, Ivette; ES
Agent:
FUSTER, Gustavo; ES
Priority Data:
P20173105329.08.2017ES
Title (EN) COMPOSITIONS ABLE TO MODULATE THE STIMULATION OF ENDOGENOUS GDNF FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) COMPOSITIONS POUVANT MODULER LA STIMULATION DE GDNF ENDOGÈNE POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
(ES) COMPOSICIONES CAPACES DE MODULAR LA ESTIMULACIÓN DE GDNF ENDÓGENO PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS
Abstract:
(EN) The invention relates to compounds and compositions able to modulate the stimulation of endogenous GDNF by means of the activation of genes GPR83, KIT, TACR1, TACR3, MC3R, RARRES2, CRABP1, MOXD1 SPATA18 and/or LHX8 or the proteins encoded by same, for the treatment of neurodegenerative diseases, and more specifically for the treatment of Parkinson's disease, and to methods for selecting said compounds and compositions.
(FR) L'invention concerne des composés et des compositions qui peuvent moduler la stimulation de GDNF endogène par activation des gènes GPR83, KIT, TACR1, TACR3, MC3R, RARRES2, CRABP1, MOXD1, SPATA18 et/ou LHX8 ou les protéines codant pour ceux-ci, pour le traitement de maladies neurodégénératives, et plus particulièrement pour le traitement de la maladie de Parkinson, ainsi que des méthodes de sélection de ces composés et compositions.
(ES) Compuestos y composiciones capaces de modular la estimulación de GDNF endógeno mediante la activación de los genes GPR83, KIT, TACRl, TACR3, MC3R, RARRES2, CRABPl, MOXDl, SPATA18 y/o LHX8 o las proteínas que codifican, para el tratamiento de enfermedades neurodegenerativas, y más específicamente para el tratamiento de la enfermedad de Parkinson, y métodos de selección de estos compuestos y composiciones.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)