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1. (WO2019043245) MICROBIAL CELLS EXPRESSING STREPTOCOCCAL SEROTYPES
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Pub. No.: WO/2019/043245 International Application No.: PCT/EP2018/073714
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
A61K 47/64 (2017.01) ,C12N 15/63 (2006.01)
[IPC code unknown for A61K 47/64]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants:
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE [GB/GB]; Keppel Street London WC1E 7HT, GB
Inventors:
KAY, Emily; GB
WREN, Brendan; GB
CUCCUI, Jon; GB
Agent:
SYMBIOSIS IP LIMITED; NAFIC Sand Hutton York YO41 1LZ, GB
Priority Data:
1714128.404.09.2017GB
1807669.511.05.2018GB
Title (EN) MICROBIAL CELLS EXPRESSING STREPTOCOCCAL SEROTYPES
(FR) CELLULES MICROBIENNES EXPRIMANT DES SÉROTYPES STREPTOCOCCIQUES
Abstract:
(EN) The disclosure relates to a glycoconjugate vaccine comprising one or more polysaccharides covalently linked to one or more carrier polypeptides wherein said glycoconjugate is manufactured by a modified microbial cell; vaccines and immunogenic compositions comprising said glycoconjugate(s); uses and methods of treatment of microbial infections using said vaccines and immunogenic compositions; bioreactors for the manufacture of said glycoconjugates and methods to prepare said glycoconjugate(s) from said modified microbial cells.
(FR) L'invention concerne un vaccin glycoconjugué comprenant un ou plusieurs polysaccharides liés de manière covalente à un ou plusieurs polypeptides porteurs, ledit glycoconjugué étant fabriqué par une cellule microbienne modifiée; des vaccins et des compositions immunogènes comprenant ledit ou lesdits glycoconjugués; des utilisations et des méthodes de traitement d'infections microbiennes à l'aide desdits vaccins et compositions immunogènes; des bioréacteurs pour la fabrication desdits glycoconjugués et des procédés de préparation dudit ou desdits glycoconjugués à partir desdites cellules microbiennes modifiées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)