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1. (WO2019043172) TRANSDERMAL DELIVERY SYSTEM INCLUDING AN EMULSIFIER
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/043172 International Application No.: PCT/EP2018/073498
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
A61K 9/70 (2006.01) ,A61K 31/196 (2006.01) ,A61K 31/33 (2006.01) ,A61K 47/34 (2017.01) ,A61P 29/00 (2006.01) ,A61P 19/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
Applicants:
LTS LOHMANN THERAPIE-SYSTEME AG [DE/DE]; Lohmannstraße 2 56626 Andernach, DE
Inventors:
WAUER, Gabriel; DE
SEIBERTZ, Frank; DE
Agent:
MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH; Eva Ehlich Elisenhof / Elisenstraße 3 80335 Munich, DE
Priority Data:
17189273.004.09.2017EP
Title (EN) TRANSDERMAL DELIVERY SYSTEM INCLUDING AN EMULSIFIER
(FR) SYSTÈME D'ADMINISTRATION TRANSDERMIQUE COMPRENANT UN ÉMULSIFIANT
Abstract:
(EN) The present invention relates to a transdermal therapeutic system (TTS) comprising an active agent-containing layer structure comprising A) a backing layer and B) a biphasic matrix layer, the biphasic matrix layer having a) a continuous, outer phase having a composition comprising 70 to 100 % by weight of at least one polymer, b) a discontinuous, inner phase having a composition comprising the active agent and a dissolver for the active agent in amount sufficient so that the active agent forms a solution with the dissolver in the inner phase and c) an emulsifier in an amount of 0.1 to 20 % by weight based on the biphasic matrix layer, processes of manufacture and uses thereof, corresponding methods of treatments therewith.
(FR) La présente invention concerne un système thérapeutique transdermique (STT) comprenant une structure de couche contenant un agent actif comprenant A) une couche de support et B) une couche de matrice biphasique, la couche de matrice biphasique ayant a) une phase externe continue ayant une composition comprenant de 70 à 100 % en poids d'au moins un polymère, b) une phase interne discontinue ayant une composition comprenant l'agent actif et un dissolveur pour l'agent actif en quantité suffisante pour que l'agent actif forme une solution avec le dissolveur dans la phase interne et c) un émulsifiant dans une quantité de 0,1 à 20 % en poids sur la base de la couche de matrice biphasique, des procédés de fabrication et des utilisations de celui-ci, ainsi que des méthodes de traitement correspondantes avec celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)