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1. (WO2019043067) METHOD FOR PURIFYING PROTEINS
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Pub. No.: WO/2019/043067 International Application No.: PCT/EP2018/073256
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07K 1/16 (2006.01) ,C07K 1/22 (2006.01) ,C07K 1/36 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
16
by chromatography
22
Affinity chromatography or related techniques based upon selective absorption processes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
14
Extraction; Separation; Purification
36
by a combination of two or more processes of different types
Applicants:
ARES TRADING S.A. [CH/CH]; Zone Industrielle de L'Ouriettaz 1170 Aubonne, CH
Inventors:
SUTTER, Harry-James; CH
LE SAOUT, Xavier; CH
FERRARIS, Albane; CH
Agent:
MERCK SERONO S.A.; Terre Bonne Business Park A2 Route de Crassier 15 1262 Eysins, CH
Priority Data:
17188659.130.08.2017EP
17199869.303.11.2017EP
Title (EN) METHOD FOR PURIFYING PROTEINS
(FR) PROCÉDÉ DE PURIFICATION DE PROTÉINES
Abstract:
(EN) The present invention relates to a method for purifying proteins, such as Fc fusion proteins or antibodies, from a sample comprising said proteins and impurities, through the use of a three- chromatographic columns procedure, including a chromatography on hydroxyapatite- and/or Fluorapatite-containing material. The invention is also concerned with pharmaceutical compositions comprising the purified proteins obtainable by the process of the invention.
(FR) La présente invention concerne un procédé de purification de protéines, telles que des protéines ou des anticorps de fusion Fc, à partir d'un échantillon comprenant lesdites protéines et impuretés, par l'utilisation d'une procédure à colonnes chromatographiques tridimensionnelles, comprenant une chromatographie sur un matériau contenant de l'hydroxyapatite et/ou du Fluorapatite. L'invention concerne également des compositions pharmaceutiques comprenant les protéines purifiées pouvant être obtenues par le procédé selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)