Processing

Please wait...

Settings

Settings

Goto Application

1. WO2019043051 - STABLE CAPSULES WITH FECAL MICROBIOTA OR A CULTURE OF MICROORGANISMS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

CLAIMS

1 . A hard capsule comprising an outer and one inner capsule, wherein the outer capsule comprises a hydrophobic liquid and the inner capsule which comprises a composition comprising uncoated microorganisms and optionally at least one desiccant.

2. A capsule according to claim 1, wherein the composition comprises at least one bacterium, archaea, fungus, or virus.

3. A capsule according to claim 1 or 2, wherein the composition comprises fecal microbiota.

4. A capsule according to claim 1 or 2, wherein the composition comprises no more than 20 different types of microorganisms.

5. A capsule according to claim 4, wherein the composition comprises no more than 20 different types of bacteria.

6. A capsule according to any one of claims 1 to 5, wherein the hydrophobic liquid is at least one edible oil.

7. A capsule according to claim 6, wherein the at least one edible oil is sunflower oil, olive oil, rapeseed oil, maize oil, soya oil, linseed oil, groundnut oil, sesame oil, rice oil, thistle oil, grape seed oil, peanut oil, coconut oil, and fish oil.

8. A capsule according to any one of claims 1 to 7, wherein the edible oil comprises at least one antioxidant.

9. A capsule according to claim 8, wherein the at least one antioxidant is ascorbyl palmitate (E304), tocopherol- rich extract (E306), alpha-tocopherol (E307), gamma-tocopherol (E308), delta-tocopherol (E309), propyl gallate (E310), octyl gallate (E311), dodecyl gallate (E312), β-carotenoids, tertiary-butyl

hydroxyquinone (TBHA) (E319), butylated hydroxyanisole (BHA) (E320), butylated hydroxytolvene (BHT) (E321), lecithin (E322), 4-hexylresorcinol

(E586), or combinations thereof.

10. A capsule according to any one of claims 1 to 9, wherein the composition

comprises at least one desiccant.

11. A capsule according to claim 10, wherein the desiccant is a food approved component which is degradable in the gastrointestinal tract.

12. A capsule according to any one of claims 1 to 11, wherein the desiccant is starch, such as potato starch, corn starch, rice starch, wheat starch, or cassava starch.

13. A capsule according to any one of claims 1 to 12, wherein the composition

comprises at least one cryoprotectant.

14. A capsule according to claim 13, wherein the cryoprotectant is glycerol,

carbohydrate, water soluble antioxidants as e.g. sodium ascorbate, glutathione, riboflavin, L-cysteine, or salts or combinations thereof.

15. A capsule according to any one of claims 1 to 14 for the use in the prevention or treatment of an infection or a disease, disorder or condition associated with a dysbiosis.