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1. (WO2019043051) STABLE CAPSULES WITH FECAL MICROBIOTA OR A CULTURE OF MICROORGANISMS
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Pub. No.: WO/2019/043051 International Application No.: PCT/EP2018/073217
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
A61K 9/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
Applicants:
CHR. HANSEN A/S [DK/DK]; Boege Alle 10-12 2970 Hoersholm, DK
Inventors:
YDE, Birgitte; DK
GÜNTHER, Stig; DK
Priority Data:
17188258.229.08.2017EP
Title (EN) STABLE CAPSULES WITH FECAL MICROBIOTA OR A CULTURE OF MICROORGANISMS
(FR) CAPSULES STABLES COMPORTANT UN MICROBIOTE FÉCAL OU UNE CULTURE DE MICRO-ORGANISMES
Abstract:
(EN) The present invention provides a hard capsule comprising an outer and one inner capsule, wherein the outer capsule comprises a hydrophobic liquid and the inner capsule which comprises a composition comprising uncoated microorganisms and optionally at least one desiccant. The composition may comprise a filtrate composed of viable fecal bacteria useful forfecal microbiota transplantation (FMT) or a mixture of one or more different types of microorganisms isolated from intestinal microbiome,such as bacteria, archaea,virus, or fungi such as yeast. The composition may comprise a desiccant, preferably a food approved component which is degradable in the gastrointestinal tract. The hydrophobic liquid, if present, is preferably at least one edible oil. Also provided are methods of treating or preventing a dysbiosis in a human subject, comprising administering to the human subject at least one capsule of the invention.
(FR) La présente invention concerne une capsule dure comprenant une capsule externe et une capsule interne, la capsule externe comprenant un liquide hydrophobe et la capsule interne comprenant une composition comprenant des micro-organismes non enrobés et éventuellement au moins un agent déshydratant. La composition peut comprendre un filtrat composé de bactéries fécales viables utiles pour la bactériothérapie fécale (FMT) ou un mélange d'un ou plusieurs types différents de micro-organismes isolés du microbiome intestinal, tels que des bactéries, des archées, des virus ou des champignons tels que la levure. La composition peut comprendre un agent déshydratant, de préférence un constituant approuvé de qualité alimentaire qui est dégradable dans le tractus gastro-intestinal. Le liquide hydrophobe, le cas échéant, est de préférence au moins une huile comestible. L'invention concerne également des méthodes de traitement ou de prévention d'une dysbiose chez un sujet humain, consistant à administrer au sujet humain au moins une capsule de l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)