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1. WO2019043051 - STABLE CAPSULES WITH FECAL MICROBIOTA OR A CULTURE OF MICROORGANISMS

Publication Number WO/2019/043051
Publication Date 07.03.2019
International Application No. PCT/EP2018/073217
International Filing Date 29.08.2018
Chapter 2 Demand Filed 28.06.2019
IPC
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
CPC
A61K 35/744
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61K 9/4808
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4808characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
A61K 9/4858
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4858Organic compounds
A61K 9/4866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4866Organic macromolecular compounds
A61K 9/4875
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4841Filling excipients; Inactive ingredients
4875Compounds of unknown constitution, e.g. material from plants or animals
Applicants
  • CHR. HANSEN A/S [DK]/[DK]
Inventors
  • YDE, Birgitte
  • GÜNTHER, Stig
Priority Data
17188258.229.08.2017EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABLE CAPSULES WITH FECAL MICROBIOTA OR A CULTURE OF MICROORGANISMS
(FR) CAPSULES STABLES COMPORTANT UN MICROBIOTE FÉCAL OU UNE CULTURE DE MICRO-ORGANISMES
Abstract
(EN)
The present invention provides a hard capsule comprising an outer and one inner capsule, wherein the outer capsule comprises a hydrophobic liquid and the inner capsule which comprises a composition comprising uncoated microorganisms and optionally at least one desiccant. The composition may comprise a filtrate composed of viable fecal bacteria useful forfecal microbiota transplantation (FMT) or a mixture of one or more different types of microorganisms isolated from intestinal microbiome,such as bacteria, archaea,virus, or fungi such as yeast. The composition may comprise a desiccant, preferably a food approved component which is degradable in the gastrointestinal tract. The hydrophobic liquid, if present, is preferably at least one edible oil. Also provided are methods of treating or preventing a dysbiosis in a human subject, comprising administering to the human subject at least one capsule of the invention.
(FR)
La présente invention concerne une capsule dure comprenant une capsule externe et une capsule interne, la capsule externe comprenant un liquide hydrophobe et la capsule interne comprenant une composition comprenant des micro-organismes non enrobés et éventuellement au moins un agent déshydratant. La composition peut comprendre un filtrat composé de bactéries fécales viables utiles pour la bactériothérapie fécale (FMT) ou un mélange d'un ou plusieurs types différents de micro-organismes isolés du microbiome intestinal, tels que des bactéries, des archées, des virus ou des champignons tels que la levure. La composition peut comprendre un agent déshydratant, de préférence un constituant approuvé de qualité alimentaire qui est dégradable dans le tractus gastro-intestinal. Le liquide hydrophobe, le cas échéant, est de préférence au moins une huile comestible. L'invention concerne également des méthodes de traitement ou de prévention d'une dysbiose chez un sujet humain, consistant à administrer au sujet humain au moins une capsule de l'invention.
Also published as
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