Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019042996) DETECTION OF T-CELLS EXPRESSING BTNL8
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/042996 International Application No.: PCT/EP2018/073124
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
G01N 33/569 (2006.01) ,C12Q 1/68 (2018.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
TRIZELL GMBH [DE/DE]; Große Bleichen 17 20354 Hamburg, DE
Inventors:
HUTCHINSON, James Alexander; DE
Agent:
UEXKÜLL & STOLBERG PARTNERSCHAFT VON PATENT- UND RECHTSANWÄLTEN MBB; Beselerstr. 4 22607 Hamburg, DE
Priority Data:
17188204.628.08.2017EP
Title (EN) DETECTION OF T-CELLS EXPRESSING BTNL8
(FR) DÉTECTION DE LYMPHOCYTES T EXPRIMANT BTNL8
Abstract:
(EN) The present invention relates to a method for detecting regulatory T cells (Tregs) in the blood of a subject by use of a novel marker. The method includes the detection of at least one commonly known marker for regulatory T cells (Tregs) in combination with the detection of the marker BTNL8. The method allows the reliable detection and quantification of different Treg populations which are involved in important immunological functions, such as immunosuppression and maintenance of immune tolerance. The invention also provides a method for monitoring the treatment of a subject suffering from an immunological disease or condition which makes use of the novel marker. The invention also relates to the use of a means that allow the specific detection of BTNL8 for detecting Tregs. Kits comprising detection means for detecting commonly known markers of Tregs along with BTNL8 are also provided.
(FR) La présente invention concerne un procédé de détection de lymphocytes T régulateurs (Treg) dans le sang d'un sujet au moyen d'un nouveau marqueur. Le procédé comprend la détection d'au moins un marqueur communément connu de lymphocytes T régulateurs (Treg) en combinaison avec la détection du marqueur BTNL8. Le procédé permet la détection et la quantification fiables de différentes populations de Treg impliquées dans des fonctions immunologiques importantes, telles que l'immunosuppression et le maintien de la tolérance immunitaire. L'invention concerne également un procédé de surveillance du traitement d'un sujet souffrant d'une maladie ou d'un état immunologique utilisant le nouveau marqueur. L'invention concerne également l'utilisation d'un moyen permettant la détection spécifique de BTNL8 afin de détecter des Treg. L'invention concerne également des kits comprenant des moyens de détection permettant de détecter des marqueurs communément connus de Treg avec BTNL8.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)