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1. (WO2019042628) ARGININE DEIMINASE ENCAPSULATED INSIDE ERYTHROCYTES AND THEIR USE IN TREATING CANCER AND ARGINASE-1 DEFICIENCY
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Pub. No.: WO/2019/042628 International Application No.: PCT/EP2018/067679
Publication Date: 07.03.2019 International Filing Date: 29.06.2018
IPC:
A61K 38/50 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
50
acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
ERYTECH PHARMA [FR/FR]; 60 avenue Rockefeller 69008 LYON, FR
Inventors:
DUFOUR, Emmanuelle; FR
BLANC, Manuel; FR
MEYZAUD, Aurélien; FR
Agent:
COLOMBET, Alain; FR
GROSBOIS, Mathilde; FR
GRAND, Guillaume; FR
MYON, Gérard; FR
VEINANTE, Aude; FR
Priority Data:
17306122.731.08.2017EP
2017-25438328.12.2017JP
Title (EN) ARGININE DEIMINASE ENCAPSULATED INSIDE ERYTHROCYTES AND THEIR USE IN TREATING CANCER AND ARGINASE-1 DEFICIENCY
(FR) ARGININE DÉIMINASE ENCAPSULÉE À L'INTÉRIEUR D'ÉRYTHROCYTES ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER ET D'UNE DÉFICIENCE EN ARGINASE-1
Abstract:
(EN) The present invention is related to arginine deiminase encapsulated into erythrocytes for use in therapy. It is in particular related to the use thereof in treating arginase-1 deficiency. Also, it relates to novel pharmaceutical compositions comprising arginine deiminase from M. arginini encapsulated into erythrocytes and the use thereof in treating diseases that may benefit from arginine depletion, such as arginine dependent cancers, in particular arginine-auxotrophic cancers, and arginase-1 deficiency.
(FR) La présente invention concerne l'arginine déiminase encapsulée dans des érythrocytes pour une utilisation en thérapie. L'invention concerne en particulier son utilisation dans le traitement d'une déficience en arginase-1. L'invention concerne également de nouvelles compositions pharmaceutiques comprenant de l'arginine déiminase issue de M. arginini encapsulée dans des érythrocytes et son utilisation dans le traitement de maladies pouvant profiter d'une déplétion d'arginine, telles que des cancers dépendant de l'arginine, en particulier des cancers auxotrophes pour l'arginine, et d'une déficience en arginase-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)