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1. WO2019042555 - MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF

Publication Number WO/2019/042555
Publication Date 07.03.2019
International Application No. PCT/EP2017/071891
International Filing Date 31.08.2017
IPC
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 16/1081
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
1081Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
Applicants
  • HUMABS BIOMED SA [CH]/[CH]
Inventors
  • CORTI, Davide
Agents
  • VON STOSCH, Andreas
  • EICHELBAUM, Kornelia
  • LEHMBACHER, Michael
  • HAHNER, Nadja
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF
(FR) ANTICORPS MULTISPÉCIFIQUES SE LIANT SPÉCIFIQUEMENT AUX ÉPITOPES DU VIRUS ZIKA ET LEURS UTILISATIONS
Abstract
(EN)
The invention relates to multispecific antibodies, and antigen binding fragments thereof, that specifically bind to distinct Zika virus epitopes and potently neutralize infection of ZIKV. The invention also relates to nucleic acids that encode such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in prophylaxis and treatment of ZIKV infection.
(FR)
L'invention concerne des anticorps multispécifiques, et des fragments de liaison à l'antigène de ceux-ci, qui se lient de manière spécifique aux épitopes du virus Zika et qui exercent une puissante activité de neutralisation d'infection par le virus Zika. L'invention concerne également des acides nucléiques codant pour de tels anticorps et fragments d'anticorps. L'invention concerne en outre l'utilisation des anticorps et des fragments d'anticorps selon l'invention dans la prophylaxie et le traitement d'infection par le virus Zika.
Latest bibliographic data on file with the International Bureau