Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019042470) BLOCKER OF CD47/SIRPα AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/042470 International Application No.: PCT/CN2018/103974
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
C07D 498/00 (2006.01) ,A61P 31/00 (2006.01) ,A61P 31/10 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10
Antimycotics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
华东理工大学 EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; 中国上海市 徐汇区梅陇路130号 No. 130 Meilong Road, Xuhui District Shanghai 200237, CN
Inventors:
李洪林 LI, Honglin; CN
朱丽丽 ZHU, Lili; CN
徐玉芳 XU, Yufang; CN
赵振江 ZHAO, Zhenjiang; CN
全丽娜 QUAN, Li'na; CN
王婉琦 WANG, Wanqi; CN
温迪莎 WEN, Disha; CN
李文杰 LI, Wenjie; CN
王艳玲 WANG, Yanling; CN
Agent:
上海一平知识产权代理有限公司 XU AND PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710785796.X04.09.2017CN
Title (EN) BLOCKER OF CD47/SIRPα AND APPLICATION THEREOF
(FR) AGENT DE BLOCAGE DE CD47/SIRPα ET APPLICATION ASSOCIÉE
(ZH) CD47/SIRPα的阻断剂及其应用
Abstract:
(EN) The present invention relates to a compound as a blocker of CD47/SIRPα interaction. In particular, the present invention relates to a compound shown in the following formula I, a pharmaceutical composition comprising the compound of formula I, and uses of the compound in treating a disease mediated by CD47/SIRPα interaction and in preparing a drug for treating the disease mediated by CD47/SIRPα interaction:
(FR) La présente invention concerne un composé en tant qu'agent de blocage de l'interaction CD47/SIRPα. En particulier, la présente invention concerne un composé représenté par la formule I suivante, une composition pharmaceutique comprenant le composé de formule I, et des utilisations du composé dans le traitement d'une maladie induite par l'interaction CD47/SIRPα, ainsi que dans la préparation d'un médicament destiné au traitement d'une maladie induite par l'interaction CD47/SIRPα.
(ZH) 本发明涉及作为CD47/SIRPα相互作用的阻断剂的化合物。具体而言,本发明涉及下式I所示化合物、含有下式I化合物的药物组合物及所述化合物在治疗CD47/SIRPα相互作用介导的疾病以及制备治疗CD47/SIRPα相互作用介导的疾病的药物中的用途:
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)