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1. (WO2019042447) NOVEL TOXIN AND METHOD FOR PREPARING INTERMEDIATE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/042447 International Application No.: PCT/CN2018/103781
Publication Date: 07.03.2019 International Filing Date: 03.09.2018
IPC:
C07D 207/448 (2006.01) ,C07D 403/12 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
44
having three double bonds between ring members or between ring members and non-ring members
444
having two doubly-bound oxygen atoms directly attached in positions 2 and 5
448
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road, Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN/CN]; 中国上海市 闵行区文井路279号 No.279 Wenjing Road, Minhang District Shanghai 200245, CN
Inventors:
许建烟 XU, Jianyan; CN
章瑛 ZHANG, Ying; CN
屈博磊 QU, Bolei; CN
蒋贵阳 JIANG, Guiyang; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟(DavidW.CHENG) David W. CHENG Level 19, Tower E3, the Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201710785396.904.09.2017CN
Title (EN) NOVEL TOXIN AND METHOD FOR PREPARING INTERMEDIATE THEREOF
(FR) NOUVELLE TOXINE ET PROCÉDÉ DE PRÉPARATION D'UN INTERMÉDIAIRE DE CELLE-CI
(ZH) 一种新毒素及其中间体的制备方法
Abstract:
(EN) A novel toxin and a method for preparing an intermediate thereof. Specifically provided are a compound as represented by formula (III) and a method for preparing same, and a method for preparing a compound as represented by formula (I) which is obtained from the compound as represented by formula (III) by means of a series of protecting group introduction, protecting group removal, and condensation reactions.
(FR) L'invention concerne une nouvelle toxine et un procédé de préparation d'un intermédiaire de celle-ci. L'invention concerne particulièrement un composé représenté par la formule (III) et son procédé de préparation, ainsi qu'un procédé de préparation d'un composé tel que représenté par la formule (I) obtenu à partir du composé tel que représenté par la formule (III) au moyen de l'introduction d'une série de groupes protecteurs, de l'élimination de groupes protecteurs et de réactions de condensation.
(ZH) 一种新毒素及其中间体的制备方法,具体包括通式(III)化合物及其制备方法,以及通式(III)化合物经过一系列的上保护基、脱保护基和缩合反应得到通式(I)化合物的制备方法。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)