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1. (WO2019042444) COMPOUND FOR INHIBITING AND DEGRADING TYROSINE PROTEIN KINASE ALK
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/042444 International Application No.: PCT/CN2018/103709
Publication Date: 07.03.2019 International Filing Date: 02.09.2018
IPC:
C07D 401/14 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
上海美志医药科技有限公司 SHANGHAI MEIZER PHARMACEUTICALS CO., LTD. [CN/CN]; 中国上海市 浦东新区万祥镇宏祥北路83弄1-42号20幢118室 Room 118 Building 20, No. 1-42, Lane 83, Hongxiang North Road Wanxiang Town, Pudong New Area Shanghai 201313, CN
Inventors:
舒永志 SHU, Yongzhi; CN
Agent:
上海德禾翰通律师事务所 DEHEHANTONG LAW FIRM; 中国上海市 徐汇区宜山路425号光启城2102室 Room 2102 21st Floor, Pole Tower, No. 425 Yishan Rd., Xuhui District Shanghai 200233, CN
Priority Data:
201710783067.003.09.2017CN
Title (EN) COMPOUND FOR INHIBITING AND DEGRADING TYROSINE PROTEIN KINASE ALK
(FR) COMPOSÉ PERMETTANT D'INHIBER ET DE DÉGRADER LA PROTÉINE TYROSINE KINASE ALK
(ZH) 一类抑制并降解酪氨酸蛋白激酶ALK的化合物
Abstract:
(EN) Provided is a compound for inhibiting and degrading tyrosine protein kinase ALK. Specifically provided is a compound as represented by the following formula I, wherein the definition of each group is as stated in the description. The compound has excellent anaplastic lymphoma kinase (ALK) inhibitory activity, and can be used for preparing drugs for treatment of ALK activity-related diseases.
(FR) L'invention concerne un composé permettant d'inhiber et de dégrader la protéine tyrosine kinase ALK. La présente invention concerne particulièrement un composé tel que représenté par la formule suivante I, dans laquelle la définition de chaque groupe est telle que décrite dans la description. Le composé présente une excellente activité inhibitrice de la kinase du lymphome anaplasique (ALK), et peut être utilisé dans la préparation de médicaments pour le traitement de maladies liées à l'activité d'ALK.
(ZH) 提供了一类抑制并降解酪氨酸蛋白激酶ALK的化合物,具体地,提供了一种如下式I所示的化合物;其中,各基团的定义如说明书中所述。该化合物具有很好的间变性淋巴瘤激酶(ALK)抑制活性,可以用于制备治疗间ALK活性相关的疾病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)