Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019042301) (E)-α,β-UNSATURATED AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/042301 International Application No.: PCT/CN2018/102824
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07C 225/14 (2006.01) ,C07C 211/02 (2006.01) ,C07C 291/02 (2006.01) ,C07D 263/30 (2006.01) ,C07D 295/088 (2006.01) ,C07D 211/68 (2006.01) ,C07D 207/18 (2006.01) ,A61P 25/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
225
Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a -CHO group, e.g. amino ketones
02
having amino groups bound to acyclic carbon atoms of the carbon skeleton
14
the carbon skeleton being unsaturated
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
02
of an acyclic saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
291
Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/-C07C281/144
02
containing nitrogen-oxide bonds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
30
having two or three double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
04
with substituted hydrocarbon radicals attached to ring nitrogen atoms
08
substituted by singly bound oxygen or sulfur atoms
084
with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
088
to an acyclic saturated chain
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68
having one double bond between ring members or between a ring member and a non-ring member
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18
having one double bond between ring members or between a ring member and a non-ring member
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
浙江海正药业股份有限公司 ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省台州市 椒江区外沙路46号 No.46 Waisha Road, Jiaojiang District Taizhou, Zhejiang 318000, CN
Inventors:
赵旭阳 ZHAO, Xuyang; CN
白骅 BAI, Hua; CN
龚永祥 GONG, Yongxiang; CN
刘礼飞 LIU, Lifei; CN
钟金清 ZHONG, Jinqing; CN
张鑫龙 ZHANG, Xinlong; CN
冯仁田 FENG, Rentian; CN
姬凯歌 JI, Kaige; CN
丁芳 DING, Fang; CN
刘伟伟 LIU, Weiwei; CN
李译 LI, Yi; CN
陈文 CHEN, Wen; CN
龚佑静 GONG, Youjing; CN
朱勇霖 ZHU, Yonglin; CN
Agent:
北京集佳知识产权代理有限公司 UNITALEN ATTORNEYS AT LAW; 中国北京市 朝阳区建国门外大街22号赛特广场7层 7th Floor, Scitech Place No.22, Jian Guo Men Wai Ave., Chao Yang District Beijing 100004, CN
Priority Data:
201710760142.129.08.2017CN
Title (EN) (E)-α,β-UNSATURATED AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
(FR) COMPOSÉ AMIDE (E)-α,β-INSATURÉ, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) (E)-α,β-不饱和酰胺化合物及其制备方法和用途
Abstract:
(EN) The present invention provides a new class of (E)-α,β-unsaturated amide compounds represented by formula I, and also relates to methods for preparing such compounds and the pharmaceutical uses thereof. The compounds have the effect of protecting nerve cells and an immunoregulatory activity. The definitions of R1, R2 and R3 in formula I are given in the description.
(FR) La présente invention concerne une nouvelle classe de composés amide (E)-α,β-insaturés représentés par la formule I, ainsi que des procédés de préparation de tels composés et leurs utilisations pharmaceutiques. Les composés possèdent un effet de protection des cellules nerveuses ainsi qu'une activité immunorégulatrice. Les définitions de R1, R2 et R3 dans la formule I sont indiquées dans la description.
(ZH) 本发明提供一类新的由式I所表示的(E)-α,β-不饱和酰胺化合物,还涉及这类化合物的制备方法及其制药用途。所述化合物具有保护神经细胞的作用和免疫调节活性。式I中R1、R2和R3的定义见说明书。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)