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1. (WO2019042282) POLYPEPTIDE AND ANTIBODY BOUND TO POLYPEPTIDE
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Pub. No.: WO/2019/042282 International Application No.: PCT/CN2018/102745
Publication Date: 07.03.2019 International Filing Date: 28.08.2018
IPC:
A61K 39/385 (2006.01) ,C07K 16/18 (2006.01) ,A61P 37/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
Applicants:
上海易乐生物技术有限公司 SHANGHAI YILE BIOTECHNOLOGY CO, . LTD. [CN/CN]; 中国上海市 徐汇区龙吴路2715号1号楼320室 Room 320, Building 1, No. 2715, Longwu Road, Xuhui District Shanghai 200231, CN
Inventors:
蔡秀梅 CAI, Xiumei; CN
戴茹萍 DAI, Ruping; CN
王华茂 WANG, Huamao; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710752743.828.08.2017CN
Title (EN) POLYPEPTIDE AND ANTIBODY BOUND TO POLYPEPTIDE
(FR) POLYPEPTIDE ET ANTICORPS LIÉ À UN POLYPEPTIDE
(ZH) 多肽及结合多肽的抗体
Abstract:
(EN) An antibody for being specifically bound to a pro brain-derived neurotrophic factor (pro-BDNF) and a bound epitope. The antibody and the protein are used for treating autoimmune diseases. By inhibiting the activity induced by the pro-BDNF, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, lupus nephriti, chronic obstructive pulmonary diseases, asthma or cystic fibrosis, multiple sclerosis and other autoimmune diseases are treated.
(FR) L'invention concerne un anticorps qui se lie spécifiquement au précurseur du facteur neurotrophique dérivé du cerveau (pro-BDNF), et un épitope lié. L'anticorps et la protéine sont utilisés pour traiter des maladies auto-immunes. L'inhibition de l'activité induite par le pro-BDNF permet de traiter la polyarthrite rhumatoïde, le psoriasis, le lupus érythémateux disséminé, la glomérulonéphrite lupique, la broncho-pneumopathie chronique obstructive, l'asthme ou la mucoviscidose, la sclérose en plaques et d'autres maladies auto-immunes.
(ZH) 特异性结合脑源性神经营养因子前体蛋白pro-BDNF的抗体及其结合表位。该抗体和蛋白用于治疗自身免疫性疾病。通过抑制pro-BDNF介导的活性来治疗,如类风湿性关节炎、银屑病、系统性红斑狼疮、狼疮性肾炎、慢性阻塞性肺疾病、哮喘或囊性纤维化、多发性硬化和其它自身免疫性和炎性病症。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)