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1. (WO2019042261) COMPOSITE HEPARIN ANTICOAGULATION COATING LIQUID, MICROSPHERES FOR COATING, PREPARATION METHOD, AND APPLICATIONS
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Pub. No.: WO/2019/042261 International Application No.: PCT/CN2018/102568
Publication Date: 07.03.2019 International Filing Date: 27.08.2018
IPC:
A61L 33/12 (2006.01) ,A61L 33/10 (2006.01) ,A61L 33/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06
Use of macromolecular materials
12
Polypeptides, proteins or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06
Use of macromolecular materials
08
Polysaccharides
10
Heparin, heparinoid or derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
04
Use of organic materials, e.g. acetylsalicylic acid
Applicants:
武汉杨森生物技术有限公司 WUHAN YOUNGSEN BIOTECH CO., LTD [CN/CN]; 中国湖北省武汉市 东湖开发区关南福星医药园3号楼9层6、7号苏凤 Sunfeng/No.6、7, Floor 9 Building 3, Guannan Fuxing Medicine Park, Wuhan East Lake High-Tech Development Zone Wuhan, Hubei 430073, CN
Inventors:
严拓 YAN, Tuo; CN
欧阳晨曦 OUYANG, Chenxi; CN
刘雅文 LIU, Yawen; CN
刘思诗 LIU, Sishi; CN
刘园 LIU, Yuan; CN
Agent:
武汉河山金堂专利事务所(普通合伙) WUHAN HESHAN JINTANG INTELLECTUAL PROPERTY CO., LTD (GENERAL PARTNERSHIP); 中国湖北省武汉市 洪山区关山大道光谷软件园区C6栋202室倪娅 Room NO.202/Ni Ya NO.C6 Building Of Guanggu Software Area, Guanshan Street, Hongshan District Wuhan, Hubei 430074, CN
Priority Data:
201710748805.828.08.2017CN
201710748820.228.08.2017CN
Title (EN) COMPOSITE HEPARIN ANTICOAGULATION COATING LIQUID, MICROSPHERES FOR COATING, PREPARATION METHOD, AND APPLICATIONS
(FR) LIQUIDE DE REVÊTEMENT ANTICOAGULATION D’HÉPARINE COMPOSITE, MICROSPHÈRES POUR REVÊTEMENT, PROCÉDÉ DE PRÉPARATION ET APPLICATIONS
(ZH) 复合肝素抗凝涂层液、涂层用微球及制备方法与应用
Abstract:
(EN) Disclosed in the present invention are a composite heparin anticoagulation coating liquid, microspheres for a coating, a preparation method, and applications. In the present invention, by means of combined use of curcumin and heparin, the anticoagulation function of a heparin coating is enhanced and the stability is further improved by means of characteristics of PLA-PEG-PLA drug-loaded sustained-release microspheres, so that tissue proliferation resistance, inflammatory reaction resistance and other functions that cannot be achieved by only using a heparin coating or a protein coating and another coating are achieved; and the present invention is critical for reducing formation of thrombus in human bodies by implantable devices such as artificial blood vessels, blood vessel stents and vascular patches, and is crucial for reducing postoperative complications and prolonging the service life of the product.
(FR) La présente invention concerne un liquide de revêtement anticoagulation d’héparine composite, des microsphères pour un revêtement, un procédé de préparation et des applications. Dans la présente invention, au moyen de l’utilisation combinée de curcumine et d’héparine, la fonction anticoagulation d’un revêtement d’héparine est augmentée et la stabilité est améliorée plus avant au moyen de caractéristiques de microsphères à libération prolongée chargées de médicament PLA-PEG-PLA, de sorte que la résistance à la prolifération tissulaire, une résistance à la réaction inflammatoire et d’autres fonctions qui ne peuvent pas être obtenues en utilisant uniquement un revêtement d’héparine ou un revêtement de protéine et un autre revêtement sont obtenus ; et la présente invention est essentielle pour réduire la formation de thrombus dans des corps humains par des dispositifs implantables tels que des vaisseaux sanguins artificiels, des stents vasculaires et des timbres vasculaires, et est essentielle pour réduire les complications postopératoires et prolonger la durée de vie du produit.
(ZH) 本发明公开了一种复合肝素抗凝涂层液、涂层用微球及制备方法与应用。本发明将姜黄素与肝素两者连用不仅可以增强肝素涂层的抗凝血功能,利用PLA-PEG-PLA载药缓释微球特性,进一步提升稳定性,起到了单纯用肝素或蛋白等涂层所无法达到的抗组织增生、抗炎性反应等功能,对于人造血管、血管支架、血管补片等植入器械在人体内减少血栓形成,降低术后并发症,提高产品的使用寿命至关重要。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)